Discovery of genomic intervals that underlie nematode responses to benzimidazoles

Parasitic nematodes impose a debilitating health and economic burden across much of the world. Nematode resistance to anthelmintic drugs threatens parasite control efforts in both human and veterinary medicine. Despite this threat, the genetic landscape of potential resistance mechanisms to these cr...

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Veröffentlicht in:	PLoS neglected tropical diseases 2018-03, Vol.12 (3), p.e0006368
Hauptverfasser:	Zamanian, Mostafa, Cook, Daniel E, Zdraljevic, Stefan, Brady, Shannon C, Lee, Daehan, Lee, Junho, Andersen, Erik C
Format:	Artikel
Sprache:	eng
Schlagworte:	Albendazole Albendazole - pharmacology Animals Anthelmintic agents Anthelmintics Anthelmintics - pharmacology Antinematodal Agents - pharmacology Antiparasitic agents Benzimidazoles Benzimidazoles - pharmacology Biology and Life Sciences Caenorhabditis - drug effects Caenorhabditis - genetics Caenorhabditis briggsae Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Control Disease Disease control Dosage and administration Drug Resistance Drug therapy Drugs Fenbendazole - pharmacology Funding Gene mapping Genes Genetic aspects Genome, Helminth - drug effects Genomes Genomics Genomics - methods Haemonchus contortus Humans Infections Interdisciplinary aspects Mebendazole Medicine Medicine and Health Sciences Molecular biology Nematoda - drug effects Nematoda - genetics Nematode Infections - drug therapy Nematodes Parasite control Parasites Parasitic diseases Parasitology Phenotype Phenotypes Phenotyping Physical Sciences Quantitative genetics Quantitative Trait Loci Research and Analysis Methods Roundworm infections Software Thiabendazole Tropical diseases Veterinary medicine
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