Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia

Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been somewhat neglected. It nevertheless represents a maj...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195876-e0195876
Hauptverfasser:	Saint-Laurent, Celine, Garcia, Stephanie, Sarrazy, Vincent, Dumas, Karine, Authier, Florence, Sore, Sophie, Tran, Albert, Gual, Philippe, Gennero, Isabelle, Salles, Jean-Pierre, Gouze, Elvire
Format:	Artikel
Sprache:	eng
Schlagworte:	Achondroplasia Achondroplasia - complications Achondroplasia - diagnosis Achondroplasia - drug therapy Achondroplasia - genetics Adipose tissue Adolescent Age Animal models Animal tissues Animals Anthropometry Biology and Life Sciences Biomarkers Blood Glucose Bone growth Cardiovascular diseases Care and treatment Child Child, Preschool Children Complications Complications and side effects Densitometers Deregulation Diabetes Diabetes mellitus Disease Disease Models, Animal Dwarfism Endocrinology and metabolism Energy metabolism Female Fibroblast growth factor receptors Fibroblasts Genetic aspects Glucose Glucose metabolism Growth factors Health aspects Health risks High fat diet Human health and pathology Humans Infant Infant, Newborn Insulin Insulin - metabolism Life Sciences Lipid Metabolism Male Medical innovations Medicine and Health Sciences Mesenchymal Stem Cells Mesenchymal Stromal Cells - metabolism Metabolism Mice Mice, Transgenic Mutation Normalizing Obesity Obesity - etiology Obesity - prevention & control Patients Pediatrics People and Places Phosphatase Receptor, Fibroblast Growth Factor, Type 3 Receptor, Fibroblast Growth Factor, Type 3 - pharmacology Receptor, Fibroblast Growth Factor, Type 3 - therapeutic use Risk factors Rodents Sabatier, Paul (1854-1941) Santé publique et épidémiologie Secondary Prevention Stem cells Therapy
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