Association of renal hyperfiltration with incident proteinuria - A nationwide registry study
To elucidate the association between renal hyperfiltration (RHF) and incident proteinuria, the data from 11,559,520 Korean adults who had undergone health screenings ≥ 3 times between 2009 and 2014 and had glomerular filtration rate (GFR) ≥60 mL/min/1.73m2 and negative dipstick test for proteinuria...
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| description | To elucidate the association between renal hyperfiltration (RHF) and incident proteinuria, the data from 11,559,520 Korean adults who had undergone health screenings ≥ 3 times between 2009 and 2014 and had glomerular filtration rate (GFR) ≥60 mL/min/1.73m2 and negative dipstick test for proteinuria at baseline, were retrospectively analyzed. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation based on serum creatinine, and RHF was defined as GFR >95th percentile adjusted for sex, age, body size, and diabetes and/or hypertension medication. The adjusted hazard ratio (aHR) of incident proteinuria in the RHF was 1.083 (95% CI, 1.069~1.097) compared to that of the non-RHF with Cox regression model. The association between RHF and incident proteinuria was not only in diabetic but also in non-diabetic subjects. This association was not observed in women (p for interaction |
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GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation based on serum creatinine, and RHF was defined as GFR >95th percentile adjusted for sex, age, body size, and diabetes and/or hypertension medication. The adjusted hazard ratio (aHR) of incident proteinuria in the RHF was 1.083 (95% CI, 1.069~1.097) compared to that of the non-RHF with Cox regression model. The association between RHF and incident proteinuria was not only in diabetic but also in non-diabetic subjects. This association was not observed in women (p for interaction <0.001). A reverse J-shaped association was found between the adjusted GFR slope and aHR of incident proteinuria. Both lower and higher GFR were associated with incident proteinuria in men. In conclusion, RHF was associated with incident proteinuria in men. Clinical studies are necessary to study whether the alleviation of RHF can prevent incident proteinuria.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0195784</identifier><identifier>PMID: 29652920</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Age ; Biology and Life Sciences ; Biomedical engineering ; Body size ; Creatinine ; Diabetes ; Diabetes mellitus ; Epidemiology ; Family medical history ; Glomerular filtration rate ; Health aspects ; Health insurance ; Health risk assessment ; Hyperfiltration ; Hypertension ; Kidney diseases ; Lifestyles ; Medical screening ; Medicine ; Medicine and Health Sciences ; Mortality ; Population ; Proteinuria ; Regression analysis ; Regression models ; Risk factors ; Transplants & implants ; Urine</subject><ispartof>PloS one, 2018-04, Vol.13 (4), p.e0195784-e0195784</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Lee et al 2018 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-18d459ba094f05f9abc3da771a5691a5a993ceae4d2a592ad7731b0f0dbd82003</citedby><cites>FETCH-LOGICAL-c692t-18d459ba094f05f9abc3da771a5691a5a993ceae4d2a592ad7731b0f0dbd82003</cites><orcidid>0000-0003-4432-4894</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898733/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898733/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29652920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Remuzzi, Giuseppe</contributor><creatorcontrib>Lee, Seung Min</creatorcontrib><creatorcontrib>Park, Ju-Young</creatorcontrib><creatorcontrib>Park, Min-Su</creatorcontrib><creatorcontrib>Park, Jong Heon</creatorcontrib><creatorcontrib>Park, Minseon</creatorcontrib><creatorcontrib>Yoon, Hyung-Jin</creatorcontrib><title>Association of renal hyperfiltration with incident proteinuria - A nationwide registry study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To elucidate the association between renal hyperfiltration (RHF) and incident proteinuria, the data from 11,559,520 Korean adults who had undergone health screenings ≥ 3 times between 2009 and 2014 and had glomerular filtration rate (GFR) ≥60 mL/min/1.73m2 and negative dipstick test for proteinuria at baseline, were retrospectively analyzed. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation based on serum creatinine, and RHF was defined as GFR >95th percentile adjusted for sex, age, body size, and diabetes and/or hypertension medication. The adjusted hazard ratio (aHR) of incident proteinuria in the RHF was 1.083 (95% CI, 1.069~1.097) compared to that of the non-RHF with Cox regression model. The association between RHF and incident proteinuria was not only in diabetic but also in non-diabetic subjects. This association was not observed in women (p for interaction <0.001). A reverse J-shaped association was found between the adjusted GFR slope and aHR of incident proteinuria. Both lower and higher GFR were associated with incident proteinuria in men. In conclusion, RHF was associated with incident proteinuria in men. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung Min</au><au>Park, Ju-Young</au><au>Park, Min-Su</au><au>Park, Jong Heon</au><au>Park, Minseon</au><au>Yoon, Hyung-Jin</au><au>Remuzzi, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of renal hyperfiltration with incident proteinuria - A nationwide registry study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-04-13</date><risdate>2018</risdate><volume>13</volume><issue>4</issue><spage>e0195784</spage><epage>e0195784</epage><pages>e0195784-e0195784</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To elucidate the association between renal hyperfiltration (RHF) and incident proteinuria, the data from 11,559,520 Korean adults who had undergone health screenings ≥ 3 times between 2009 and 2014 and had glomerular filtration rate (GFR) ≥60 mL/min/1.73m2 and negative dipstick test for proteinuria at baseline, were retrospectively analyzed. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation based on serum creatinine, and RHF was defined as GFR >95th percentile adjusted for sex, age, body size, and diabetes and/or hypertension medication. The adjusted hazard ratio (aHR) of incident proteinuria in the RHF was 1.083 (95% CI, 1.069~1.097) compared to that of the non-RHF with Cox regression model. The association between RHF and incident proteinuria was not only in diabetic but also in non-diabetic subjects. This association was not observed in women (p for interaction <0.001). A reverse J-shaped association was found between the adjusted GFR slope and aHR of incident proteinuria. Both lower and higher GFR were associated with incident proteinuria in men. In conclusion, RHF was associated with incident proteinuria in men. Clinical studies are necessary to study whether the alleviation of RHF can prevent incident proteinuria.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29652920</pmid><doi>10.1371/journal.pone.0195784</doi><tpages>e0195784</tpages><orcidid>https://orcid.org/0000-0003-4432-4894</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Age Biology and Life Sciences Biomedical engineering Body size Creatinine Diabetes Diabetes mellitus Epidemiology Family medical history Glomerular filtration rate Health aspects Health insurance Health risk assessment Hyperfiltration Hypertension Kidney diseases Lifestyles Medical screening Medicine Medicine and Health Sciences Mortality Population Proteinuria Regression analysis Regression models Risk factors Transplants & implants Urine |
| title | Association of renal hyperfiltration with incident proteinuria - A nationwide registry study |
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