Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

The sodium-independent cystine-glutamate antiporter plays an important role in extracellular cystine uptake. It comprises the transmembrane protein, xCT and its chaperone, CD98. Because glutathione is only weakly cell membrane permeable, cellular uptake of its precursor, cystine, is known to be a ke...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195151-e0195151
Hauptverfasser:	Nagane, Masaki, Kanai, Eiichi, Shibata, Yuki, Shimizu, Takuto, Yoshioka, Chie, Maruo, Takuya, Yamashita, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Arthritis Biochemistry Biology and life sciences Biosynthesis Breast cancer Cancer therapies Cell cycle Cystine Deoxyribonucleic acid DNA DNA damage DNA repair Dosage and administration Drug therapy Embryo fibroblasts Embryos Fibroblasts Glutathione Hydrogen peroxide Immunoglobulins Inflammatory bowel disease Inhibitors Irradiation Laboratories Medicine and Health Sciences Melanoma Membrane proteins Oxidative stress Polymerase chain reaction Radiation Radiation damage Radiation therapy Radiosensitivity Repair Rodents Senescence Sensitizing Sodium Sulfasalazine Tumors Veterinary colleges Veterinary medicine Veterinary services X-rays
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