Electrophysiological mechanisms of vandetanib-induced cardiotoxicity: Comparison of action potentials in rabbit Purkinje fibers and pluripotent stem cell-derived cardiomyocytes

Vandetanib, a multi-kinase inhibitor used for the treatment of various cancers, has been reported to induce several adverse cardiac effects. However, the underlying mechanisms of vandetanib-induced cardiotoxicity are unclear. This study aimed to investigate the mechanism of vandetanib-induced cardio...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195577
Hauptverfasser:	Lee, Hyang-Ae, Hyun, Sung-Ae, Byun, Byungjin, Chae, Jong-Hak, Kim, Ki-Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Alanine Animal models Animals Arrhythmia Biology and Life Sciences Cardiac arrhythmia Cardiomyocytes Cardiotoxicity Cardiotoxicity - physiopathology Cardiotoxins - chemistry Cardiotoxins - toxicity Cardiovascular diseases Complications and side effects Depolarization Docking Drugs Electrophysiological Phenomena Electrophysiology Engineering and Technology Enzyme inhibitors ERG1 Potassium Channel - chemistry ERG1 Potassium Channel - genetics ERG1 Potassium Channel - metabolism Female Fibers Growth factors Health aspects Heart diseases HEK293 Cells Human influences Humans In Vitro Techniques Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - physiology Ion channels KCNQ1 Potassium Channel - genetics KCNQ1 Potassium Channel - metabolism KCNQ1 protein Kinases Laboratory animals Medical screening Medicine and Health Sciences Models, Molecular Mutagenesis Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology NAV1.5 Voltage-Gated Sodium Channel - genetics NAV1.5 Voltage-Gated Sodium Channel - metabolism Oncology Patch-Clamp Techniques Pharmacology Physical Sciences Piperidines - chemistry Piperidines - toxicity Pluripotency Potassium channels Potassium channels (delayed-rectifying) Potassium channels (inwardly-rectifying) Potassium channels (voltage-gated) Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - toxicity Purkinje fibers Purkinje Fibers - drug effects Purkinje Fibers - physiopathology Quinazolines - chemistry Quinazolines - toxicity Rabbits Rectifiers Research and Analysis Methods Risk factors Stem cells Toxicology Vandetanib
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