p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development
Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a transcription factor that commands the cellular response to different types of stresses. In adult...
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| creator | Contreras, Esteban G Sierralta, Jimena Glavic, Alvaro |
| description | Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a transcription factor that commands the cellular response to different types of stresses. In adult Drosophila melanogaster, p53 regulates the metabolic adaptation to nutrient restriction that supports fly viability. Furthermore, the larval brain is protected from nutrient restriction in a phenomenon called 'brain sparing'. Therefore, we hypothesised that p53 may regulate brain growth and show a protective role over brain development under nutrient restriction.
Here, we studied the function of p53 during brain growth in normal conditions and in animals subjected to developmental nutrient restriction. We showed that p53 loss of function reduced animal growth and larval brain size. Endogenous p53 was expressed in larval neural stem cells, but its levels and activity were not affected by nutritional stress. Interestingly, p53 knockdown only in neural stem cells was sufficient to decrease larval brain growth. Finally, we showed that in p53 mutant larvae under nutrient restriction, the energy storage levels were not altered, and these larvae generated adults with brains of similar size than wild-type animals.
Using genetic approaches, we demonstrate that p53 is required for proper growth of the larval brain. This developmental role of p53 does not have an impact on animal resistance to nutritional stress since brain growth in p53 mutants under nutrient restriction is similar to control animals. |
| doi_str_mv | 10.1371/journal.pone.0194344 |
| format | Article |
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Here, we studied the function of p53 during brain growth in normal conditions and in animals subjected to developmental nutrient restriction. We showed that p53 loss of function reduced animal growth and larval brain size. Endogenous p53 was expressed in larval neural stem cells, but its levels and activity were not affected by nutritional stress. Interestingly, p53 knockdown only in neural stem cells was sufficient to decrease larval brain growth. Finally, we showed that in p53 mutant larvae under nutrient restriction, the energy storage levels were not altered, and these larvae generated adults with brains of similar size than wild-type animals.
Using genetic approaches, we demonstrate that p53 is required for proper growth of the larval brain. This developmental role of p53 does not have an impact on animal resistance to nutritional stress since brain growth in p53 mutants under nutrient restriction is similar to control animals.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0194344</identifier><identifier>PMID: 29621246</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptation ; Adults ; Analysis ; Animal growth ; Animals ; Apoptosis ; Biology and Life Sciences ; Brain ; Cell cycle ; Deoxyribonucleic acid ; DNA ; Drosophila ; Energy storage ; Genes ; Genomes ; Growth ; Impact resistance ; Insects ; Larvae ; Larval development ; Medicine and Health Sciences ; Metabolism ; Mutants ; Neural stem cells ; Neurosciences ; Nutrient availability ; Nutrient deficiency ; Nutrient loss ; Nutrients ; p53 Protein ; Research and Analysis Methods ; Stem cell transplantation ; Stem cells ; Transcription factors ; Viability</subject><ispartof>PloS one, 2018-04, Vol.13 (4), p.e0194344-e0194344</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Contreras et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Contreras et al 2018 Contreras et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4355e21e48f5e1e8b64d5b2a363fa020aecfef35dd1e5b670849f74737885a0e3</citedby><cites>FETCH-LOGICAL-c692t-4355e21e48f5e1e8b64d5b2a363fa020aecfef35dd1e5b670849f74737885a0e3</cites><orcidid>0000-0002-7330-7623</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886404/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886404/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29621246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Missirlis, Fanis</contributor><creatorcontrib>Contreras, Esteban G</creatorcontrib><creatorcontrib>Sierralta, Jimena</creatorcontrib><creatorcontrib>Glavic, Alvaro</creatorcontrib><title>p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a transcription factor that commands the cellular response to different types of stresses. In adult Drosophila melanogaster, p53 regulates the metabolic adaptation to nutrient restriction that supports fly viability. Furthermore, the larval brain is protected from nutrient restriction in a phenomenon called 'brain sparing'. Therefore, we hypothesised that p53 may regulate brain growth and show a protective role over brain development under nutrient restriction.
Here, we studied the function of p53 during brain growth in normal conditions and in animals subjected to developmental nutrient restriction. We showed that p53 loss of function reduced animal growth and larval brain size. Endogenous p53 was expressed in larval neural stem cells, but its levels and activity were not affected by nutritional stress. Interestingly, p53 knockdown only in neural stem cells was sufficient to decrease larval brain growth. Finally, we showed that in p53 mutant larvae under nutrient restriction, the energy storage levels were not altered, and these larvae generated adults with brains of similar size than wild-type animals.
Using genetic approaches, we demonstrate that p53 is required for proper growth of the larval brain. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Contreras, Esteban G</au><au>Sierralta, Jimena</au><au>Glavic, Alvaro</au><au>Missirlis, Fanis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-04-05</date><risdate>2018</risdate><volume>13</volume><issue>4</issue><spage>e0194344</spage><epage>e0194344</epage><pages>e0194344-e0194344</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a transcription factor that commands the cellular response to different types of stresses. In adult Drosophila melanogaster, p53 regulates the metabolic adaptation to nutrient restriction that supports fly viability. Furthermore, the larval brain is protected from nutrient restriction in a phenomenon called 'brain sparing'. Therefore, we hypothesised that p53 may regulate brain growth and show a protective role over brain development under nutrient restriction.
Here, we studied the function of p53 during brain growth in normal conditions and in animals subjected to developmental nutrient restriction. We showed that p53 loss of function reduced animal growth and larval brain size. Endogenous p53 was expressed in larval neural stem cells, but its levels and activity were not affected by nutritional stress. Interestingly, p53 knockdown only in neural stem cells was sufficient to decrease larval brain growth. Finally, we showed that in p53 mutant larvae under nutrient restriction, the energy storage levels were not altered, and these larvae generated adults with brains of similar size than wild-type animals.
Using genetic approaches, we demonstrate that p53 is required for proper growth of the larval brain. This developmental role of p53 does not have an impact on animal resistance to nutritional stress since brain growth in p53 mutants under nutrient restriction is similar to control animals.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29621246</pmid><doi>10.1371/journal.pone.0194344</doi><tpages>e0194344</tpages><orcidid>https://orcid.org/0000-0002-7330-7623</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Adults Analysis Animal growth Animals Apoptosis Biology and Life Sciences Brain Cell cycle Deoxyribonucleic acid DNA Drosophila Energy storage Genes Genomes Growth Impact resistance Insects Larvae Larval development Medicine and Health Sciences Metabolism Mutants Neural stem cells Neurosciences Nutrient availability Nutrient deficiency Nutrient loss Nutrients p53 Protein Research and Analysis Methods Stem cell transplantation Stem cells Transcription factors Viability |
| title | p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development |
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