IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have been marginal and long-term survivorship is uncommon. Thus, new targets for therapeutics are critically...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0193565-e0193565
Hauptverfasser:	Berlow, Noah E, Svalina, Matthew N, Quist, Michael J, Settelmeyer, Teagan P, Zherebitskiy, Viktor, Kogiso, Mari, Qi, Lin, Du, Yuchen, Hawkins, Cynthia E, Hulleman, Esther, Li, Xiao-Nan, Gultekin, Sakir H, Keller, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology and life sciences Brain Brain cancer Brain research Brain tumors c-Met protein Cancer Cancer therapies Cell surface Chemotherapy Children Children & youth Clinical trials Cytokines Deoxyribonucleic acid DNA DNA sequencing Epidermal growth factor Epidermal growth factor receptors Gene expression Gene sequencing Genomes Glioma Gliomas Immunohistochemistry Immunotherapy Interleukin 13 Interleukin 4 Kinases Medical prognosis Medical research Medicine and Health Sciences Pathology Patient outcomes Patients Pediatrics Radiation therapy Receptors Research and Analysis Methods Ribonucleic acid RNA RNA sequencing Signaling Survival Therapeutic applications Transcription Tumors
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