Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection

Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T cell responses, while virus-specific T cells in chronic hepatitis B (CHB) are rare and exhibit immune exhaustion that includes programmed-death-1 (PD-1) expression on virus-specific T cells. Thus, an immunot...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0190058
Hauptverfasser:	Balsitis, Scott, Gali, Volodymyr, Mason, Pamela J, Chaniewski, Susan, Levine, Steven M, Wichroski, Michael J, Feulner, Michael, Song, Yunling, Granaldi, Karen, Loy, James K, Thompson, Chris M, Lesniak, Jacob A, Brockus, Catherine, Kishnani, Narendra, Menne, Stephan, Cockett, Mark I, Iyer, Renuka, Mason, Stephen W, Tenney, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antigenemia Antigens Antiviral drugs B7-H1 Antigen - immunology Biology and Life Sciences Cancer therapies Care and treatment CD8 antigen Chief executive officers Complications and side effects Disease Models, Animal Drug resistance Effectiveness Enzyme-linked immunosorbent assay Exhaustion Generic drugs Genomes Health risks Hepatitis Hepatitis B Hepatitis B - therapy Immune clearance Immune response Immunotherapy Infections Interferon Liver Liver diseases Lymphocytes Lymphocytes T Marmota Medicine and Health Sciences Melanoma Monoclonal antibodies Oncology Patients PD-1 protein PD-L1 protein Physiological aspects Product safety Reagents Research and Analysis Methods Risk assessment Safety Sag Seroconversion Statistical analysis Therapy Toxicology Viremia Virology Viruses Woodchuck γ-Interferon
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