Natural Schistosoma mansoni Infection in the Wild Reservoir Nectomys squamipes Leads to Excessive Lipid Droplet Accumulation in Hepatocytes in the Absence of Liver Functional Impairment

Schistosomiasis is a neglected tropical disease of a significant public health impact. The water rat Nectomys squamipes is one of the most important non-human hosts in the schistosomiasis mansoni transmission in Brazil, being considered a wild reservoir. Cellular mechanisms that contribute to the ph...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166979
Hauptverfasser:	Amaral, Kátia B, Silva, Thiago P, Malta, Kássia K, Carmo, Lívia A S, Dias, Felipe F, Almeida, Mariana R, Andrade, Gustavo F S, Martins, Jefferson S, Pinho, Roberto R, Costa-Neto, Sócrates F, Gentile, Rosana, Melo, Rossana C N
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Analysis Animals Arachidonic acid Arvicolinae - metabolism Arvicolinae - parasitology Biology and Life Sciences Cellular biology Cholesterol Fatty acids Fatty Acids, Omega-6 - metabolism Fatty liver Fatty Liver - metabolism Fatty Liver - parasitology Health aspects Hepatocytes Hepatocytes - metabolism Hepatocytes - parasitology Humans Infections Inflammation Laboratories Lipid Droplets - metabolism Lipids Liver Liver - metabolism Liver - parasitology Mass spectroscopy Medicine and Health Sciences Nectomys squamipes Parasites Parasitology Polyunsaturated fatty acids Public health Raman spectroscopy Rats Risk factors Rodents Schistosoma Schistosoma mansoni Schistosomiasis Schistosomiasis mansoni - metabolism Spectroscopy Steatosis Transaminases Triglycerides Tropical diseases
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