Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
This study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM). Sixty-four people with...
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| creator | Moser, Othmar Eckstein, Max L McCarthy, Olivia Deere, Rachel Bain, Stephen C Haahr, Hanne L Zijlstra, Eric Heise, Tim Bracken, Richard M |
| description | This study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).
Sixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.
We found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).
Our data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM. |
| doi_str_mv | 10.1371/journal.pone.0194750 |
| format | Article |
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Sixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.
We found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).
Our data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0194750</identifier><identifier>PMID: 29608593</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aerobic exercises ; Anthropometry ; Biology and life sciences ; Body measurements ; Cardiovascular disease ; Clinical medicine ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Engineering schools ; Exercise ; Exhaustion ; Females ; Glucose ; Heart failure ; Heart rate ; Hemoglobin ; Markers ; Maximum power ; Measurement ; Medical schools ; Medicine ; Medicine and health sciences ; Metabolism ; Mortality ; Physical fitness ; Physical Sciences ; Physical training ; Physiological aspects ; Physiology ; Regression analysis ; Research and Analysis Methods ; Studies ; Type 1 diabetes</subject><ispartof>PloS one, 2018-04, Vol.13 (4), p.e0194750-e0194750</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Moser et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Moser et al 2018 Moser et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d0bebe9e3a21fba55dc46e8f0065d84769a0b553ab0dca6df8b061550a3f2a673</citedby><cites>FETCH-LOGICAL-c692t-d0bebe9e3a21fba55dc46e8f0065d84769a0b553ab0dca6df8b061550a3f2a673</cites><orcidid>0000-0002-1661-0685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880363/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880363/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29608593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bjornstad, Petter</contributor><creatorcontrib>Moser, Othmar</creatorcontrib><creatorcontrib>Eckstein, Max L</creatorcontrib><creatorcontrib>McCarthy, Olivia</creatorcontrib><creatorcontrib>Deere, Rachel</creatorcontrib><creatorcontrib>Bain, Stephen C</creatorcontrib><creatorcontrib>Haahr, Hanne L</creatorcontrib><creatorcontrib>Zijlstra, Eric</creatorcontrib><creatorcontrib>Heise, Tim</creatorcontrib><creatorcontrib>Bracken, Richard M</creatorcontrib><title>Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).
Sixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.
We found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).
Our data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.</description><subject>Aerobic exercises</subject><subject>Anthropometry</subject><subject>Biology and life sciences</subject><subject>Body measurements</subject><subject>Cardiovascular disease</subject><subject>Clinical medicine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Engineering schools</subject><subject>Exercise</subject><subject>Exhaustion</subject><subject>Females</subject><subject>Glucose</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Hemoglobin</subject><subject>Markers</subject><subject>Maximum power</subject><subject>Measurement</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and health sciences</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Physical fitness</subject><subject>Physical Sciences</subject><subject>Physical training</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Studies</subject><subject>Type 1 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rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes</title><author>Moser, Othmar ; Eckstein, Max L ; McCarthy, Olivia ; Deere, Rachel ; Bain, Stephen C ; Haahr, Hanne L ; Zijlstra, Eric ; Heise, Tim ; Bracken, Richard M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d0bebe9e3a21fba55dc46e8f0065d84769a0b553ab0dca6df8b061550a3f2a673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aerobic exercises</topic><topic>Anthropometry</topic><topic>Biology and life sciences</topic><topic>Body measurements</topic><topic>Cardiovascular disease</topic><topic>Clinical medicine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Engineering 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Petter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-04-02</date><risdate>2018</risdate><volume>13</volume><issue>4</issue><spage>e0194750</spage><epage>e0194750</epage><pages>e0194750-e0194750</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).
Sixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.
We found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).
Our data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29608593</pmid><doi>10.1371/journal.pone.0194750</doi><tpages>e0194750</tpages><orcidid>https://orcid.org/0000-0002-1661-0685</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aerobic exercises Anthropometry Biology and life sciences Body measurements Cardiovascular disease Clinical medicine Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Engineering schools Exercise Exhaustion Females Glucose Heart failure Heart rate Hemoglobin Markers Maximum power Measurement Medical schools Medicine Medicine and health sciences Metabolism Mortality Physical fitness Physical Sciences Physical training Physiological aspects Physiology Regression analysis Research and Analysis Methods Studies Type 1 diabetes |
| title | Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T05%3A30%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heart%20rate%20dynamics%20during%20cardio-pulmonary%20exercise%20testing%20are%20associated%20with%20glycemic%20control%20in%20individuals%20with%20type%201%20diabetes&rft.jtitle=PloS%20one&rft.au=Moser,%20Othmar&rft.date=2018-04-02&rft.volume=13&rft.issue=4&rft.spage=e0194750&rft.epage=e0194750&rft.pages=e0194750-e0194750&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0194750&rft_dat=%3Cgale_plos_%3EA533041353%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2020851107&rft_id=info:pmid/29608593&rft_galeid=A533041353&rft_doaj_id=oai_doaj_org_article_46b6808659884410be1b568d589f1976&rfr_iscdi=true |