Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model
Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the developmen...
Gespeichert in:
| Veröffentlicht in: | PloS one 2018-03, Vol.13 (3), p.e0195411-e0195411 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0195411 |
|---|---|
| container_issue | 3 |
| container_start_page | e0195411 |
| container_title | PloS one |
| container_volume | 13 |
| creator | Liu, Lijie Huang, Yi Fang, Cong Zhang, Hongyu Yang, Jing Xuan, Chuanying Wang, Fanfan Lu, Haiying Cao, Shuangfeng Wang, Yongfang Li, Shengwei Sha, Jun Zha, Mingming Guo, Min Wang, Jian |
| description | Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM. |
| doi_str_mv | 10.1371/journal.pone.0195411 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2020019066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A532816160</galeid><doaj_id>oai_doaj_org_article_0854c2efbf174d818f75cb5ba5419c45</doaj_id><sourcerecordid>A532816160</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-a954514980ecc37abb2c93ece8bb0cc95d45377624264adaa4bce819dc7fb9613</originalsourceid><addsrcrecordid>eNqNk9tq3DAQhk1padJt36C0gkJpL7yV5PNNISw9LAQCPd2KsTxea7GljSSX5Bn60tXuOmFdclF8ITPzzS_NL00UvWR0yZKCfdia0WrolzujcUlZlaWMPYrOWZXwOOc0eXzyfxY9c25LaZaUef40OuNVTllO8_Poz6qzRitJtFEOY7zZGTdaJHgDEm0NHh1R2o290sSiU86DlkhAN2RnzWD2ed8hGUCrFkPWK6MdMe0h6m93SDhpFNR4VCJAOrXp4hZ8CKMngxldKDcN9s-jJy30Dl9M6yL6-fnTj9XX-PLqy3p1cRnLIit9DKHVjKVVSVHKpIC65rJKUGJZ11TKKmvSLCmKnKc8T6EBSOuQY1Uji7aucpYsotdH3V1vnJh8dIJTToOPNM8DsT4SjYGt2Fk1gL0VBpQ4BIzdCLBeyR4FLbNUcmzrlhVpU7KyLTJZZzWE-6hkOMki-jjtNtYDNhK1t9DPROcZrTqxMb9FVhZFWfAg8G4SsOZ6DB6LQTmJfQ8ag3mHc6cl47QI6Jt_0Ie7m6gNhAaUbk3YV-5FxUWW8JLl4W0EavkAFb4GByXDo2tViM8K3s8KAuPxxm9gdE6sv3_7f_bq15x9e8J2CL3vnOnHw0ubg-kRlNY4Z7G9N5lRsZ-ZOzfEfmbENDOh7NXpBd0X3Q1J8hd0CxNl</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2020019066</pqid></control><display><type>article</type><title>Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Liu, Lijie ; Huang, Yi ; Fang, Cong ; Zhang, Hongyu ; Yang, Jing ; Xuan, Chuanying ; Wang, Fanfan ; Lu, Haiying ; Cao, Shuangfeng ; Wang, Yongfang ; Li, Shengwei ; Sha, Jun ; Zha, Mingming ; Guo, Min ; Wang, Jian</creator><contributor>Aguila, Marcia B.</contributor><creatorcontrib>Liu, Lijie ; Huang, Yi ; Fang, Cong ; Zhang, Hongyu ; Yang, Jing ; Xuan, Chuanying ; Wang, Fanfan ; Lu, Haiying ; Cao, Shuangfeng ; Wang, Yongfang ; Li, Shengwei ; Sha, Jun ; Zha, Mingming ; Guo, Min ; Wang, Jian ; Aguila, Marcia B.</creatorcontrib><description>Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0195411</identifier><identifier>PMID: 29601606</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Biology and Life Sciences ; Carbohydrates ; Care and treatment ; Chronic illnesses ; Complications and side effects ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diet ; Diet therapy ; Dyslipidemia ; Engineering and Technology ; Environmental aspects ; Epidemiology ; Exposure ; Fatty acids ; Feeds ; Glucose tolerance ; Health risks ; High fat diet ; Hyperglycemia ; Insulin ; Insulin resistance ; Intolerance ; Laboratory animals ; Life sciences ; Lipolysis ; Medicine and Health Sciences ; Metabolism ; Methods ; Mice ; Neurosciences ; Noise ; Noise levels ; Noise pollution ; Occupational exposure ; Occupational safety ; Physical Sciences ; Physiology ; Proteins ; Rodents ; Type 2 diabetes</subject><ispartof>PloS one, 2018-03, Vol.13 (3), p.e0195411-e0195411</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Liu et al 2018 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-a954514980ecc37abb2c93ece8bb0cc95d45377624264adaa4bce819dc7fb9613</citedby><cites>FETCH-LOGICAL-c758t-a954514980ecc37abb2c93ece8bb0cc95d45377624264adaa4bce819dc7fb9613</cites><orcidid>0000-0002-8309-609X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877872/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877872/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29601606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aguila, Marcia B.</contributor><creatorcontrib>Liu, Lijie</creatorcontrib><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Fang, Cong</creatorcontrib><creatorcontrib>Zhang, Hongyu</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Xuan, Chuanying</creatorcontrib><creatorcontrib>Wang, Fanfan</creatorcontrib><creatorcontrib>Lu, Haiying</creatorcontrib><creatorcontrib>Cao, Shuangfeng</creatorcontrib><creatorcontrib>Wang, Yongfang</creatorcontrib><creatorcontrib>Li, Shengwei</creatorcontrib><creatorcontrib>Sha, Jun</creatorcontrib><creatorcontrib>Zha, Mingming</creatorcontrib><creatorcontrib>Guo, Min</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><title>Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM.</description><subject>Abnormalities</subject><subject>Biology and Life Sciences</subject><subject>Carbohydrates</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diet</subject><subject>Diet therapy</subject><subject>Dyslipidemia</subject><subject>Engineering and Technology</subject><subject>Environmental aspects</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Fatty acids</subject><subject>Feeds</subject><subject>Glucose tolerance</subject><subject>Health risks</subject><subject>High fat diet</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Intolerance</subject><subject>Laboratory animals</subject><subject>Life sciences</subject><subject>Lipolysis</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Mice</subject><subject>Neurosciences</subject><subject>Noise</subject><subject>Noise levels</subject><subject>Noise pollution</subject><subject>Occupational exposure</subject><subject>Occupational safety</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padJt36C0gkJpL7yV5PNNISw9LAQCPd2KsTxea7GljSSX5Bn60tXuOmFdclF8ITPzzS_NL00UvWR0yZKCfdia0WrolzujcUlZlaWMPYrOWZXwOOc0eXzyfxY9c25LaZaUef40OuNVTllO8_Poz6qzRitJtFEOY7zZGTdaJHgDEm0NHh1R2o290sSiU86DlkhAN2RnzWD2ed8hGUCrFkPWK6MdMe0h6m93SDhpFNR4VCJAOrXp4hZ8CKMngxldKDcN9s-jJy30Dl9M6yL6-fnTj9XX-PLqy3p1cRnLIit9DKHVjKVVSVHKpIC65rJKUGJZ11TKKmvSLCmKnKc8T6EBSOuQY1Uji7aucpYsotdH3V1vnJh8dIJTToOPNM8DsT4SjYGt2Fk1gL0VBpQ4BIzdCLBeyR4FLbNUcmzrlhVpU7KyLTJZZzWE-6hkOMki-jjtNtYDNhK1t9DPROcZrTqxMb9FVhZFWfAg8G4SsOZ6DB6LQTmJfQ8ag3mHc6cl47QI6Jt_0Ie7m6gNhAaUbk3YV-5FxUWW8JLl4W0EavkAFb4GByXDo2tViM8K3s8KAuPxxm9gdE6sv3_7f_bq15x9e8J2CL3vnOnHw0ubg-kRlNY4Z7G9N5lRsZ-ZOzfEfmbENDOh7NXpBd0X3Q1J8hd0CxNl</recordid><startdate>20180330</startdate><enddate>20180330</enddate><creator>Liu, Lijie</creator><creator>Huang, Yi</creator><creator>Fang, Cong</creator><creator>Zhang, Hongyu</creator><creator>Yang, Jing</creator><creator>Xuan, Chuanying</creator><creator>Wang, Fanfan</creator><creator>Lu, Haiying</creator><creator>Cao, Shuangfeng</creator><creator>Wang, Yongfang</creator><creator>Li, Shengwei</creator><creator>Sha, Jun</creator><creator>Zha, Mingming</creator><creator>Guo, Min</creator><creator>Wang, Jian</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8309-609X</orcidid></search><sort><creationdate>20180330</creationdate><title>Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model</title><author>Liu, Lijie ; Huang, Yi ; Fang, Cong ; Zhang, Hongyu ; Yang, Jing ; Xuan, Chuanying ; Wang, Fanfan ; Lu, Haiying ; Cao, Shuangfeng ; Wang, Yongfang ; Li, Shengwei ; Sha, Jun ; Zha, Mingming ; Guo, Min ; Wang, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-a954514980ecc37abb2c93ece8bb0cc95d45377624264adaa4bce819dc7fb9613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abnormalities</topic><topic>Biology and Life Sciences</topic><topic>Carbohydrates</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diet</topic><topic>Diet therapy</topic><topic>Dyslipidemia</topic><topic>Engineering and Technology</topic><topic>Environmental aspects</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Fatty acids</topic><topic>Feeds</topic><topic>Glucose tolerance</topic><topic>Health risks</topic><topic>High fat diet</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Intolerance</topic><topic>Laboratory animals</topic><topic>Life sciences</topic><topic>Lipolysis</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Methods</topic><topic>Mice</topic><topic>Neurosciences</topic><topic>Noise</topic><topic>Noise levels</topic><topic>Noise pollution</topic><topic>Occupational exposure</topic><topic>Occupational safety</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lijie</creatorcontrib><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Fang, Cong</creatorcontrib><creatorcontrib>Zhang, Hongyu</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Xuan, Chuanying</creatorcontrib><creatorcontrib>Wang, Fanfan</creatorcontrib><creatorcontrib>Lu, Haiying</creatorcontrib><creatorcontrib>Cao, Shuangfeng</creatorcontrib><creatorcontrib>Wang, Yongfang</creatorcontrib><creatorcontrib>Li, Shengwei</creatorcontrib><creatorcontrib>Sha, Jun</creatorcontrib><creatorcontrib>Zha, Mingming</creatorcontrib><creatorcontrib>Guo, Min</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lijie</au><au>Huang, Yi</au><au>Fang, Cong</au><au>Zhang, Hongyu</au><au>Yang, Jing</au><au>Xuan, Chuanying</au><au>Wang, Fanfan</au><au>Lu, Haiying</au><au>Cao, Shuangfeng</au><au>Wang, Yongfang</au><au>Li, Shengwei</au><au>Sha, Jun</au><au>Zha, Mingming</au><au>Guo, Min</au><au>Wang, Jian</au><au>Aguila, Marcia B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-03-30</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>e0195411</spage><epage>e0195411</epage><pages>e0195411-e0195411</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29601606</pmid><doi>10.1371/journal.pone.0195411</doi><tpages>e0195411</tpages><orcidid>https://orcid.org/0000-0002-8309-609X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-03, Vol.13 (3), p.e0195411-e0195411 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2020019066 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Biology and Life Sciences Carbohydrates Care and treatment Chronic illnesses Complications and side effects Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Diet therapy Dyslipidemia Engineering and Technology Environmental aspects Epidemiology Exposure Fatty acids Feeds Glucose tolerance Health risks High fat diet Hyperglycemia Insulin Insulin resistance Intolerance Laboratory animals Life sciences Lipolysis Medicine and Health Sciences Metabolism Methods Mice Neurosciences Noise Noise levels Noise pollution Occupational exposure Occupational safety Physical Sciences Physiology Proteins Rodents Type 2 diabetes |
| title | Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T11%3A28%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20noise-exposure%20exacerbates%20insulin%20resistance%20and%20promotes%20the%20manifestations%20of%20the%20type%202%20diabetes%20in%20a%20high-fat%20diet%20mouse%20model&rft.jtitle=PloS%20one&rft.au=Liu,%20Lijie&rft.date=2018-03-30&rft.volume=13&rft.issue=3&rft.spage=e0195411&rft.epage=e0195411&rft.pages=e0195411-e0195411&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0195411&rft_dat=%3Cgale_plos_%3EA532816160%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2020019066&rft_id=info:pmid/29601606&rft_galeid=A532816160&rft_doaj_id=oai_doaj_org_article_0854c2efbf174d818f75cb5ba5419c45&rfr_iscdi=true |