The characteristics of premature infants with transient corneal haze
The etiology of transient corneal haze in premature infants is not known and how it relates to clinical outcomes in premature infants is not clear. To study associated factors of transient corneal haze in premature infants. We performed a retrospective study of 261 premature infants from retinopathy...
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| Veröffentlicht in: | PloS one 2018-03, Vol.13 (3), p.e0195300-e0195300 |
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| description | The etiology of transient corneal haze in premature infants is not known and how it relates to clinical outcomes in premature infants is not clear.
To study associated factors of transient corneal haze in premature infants.
We performed a retrospective study of 261 premature infants from retinopathy of prematurity (ROP) screening in the neonatal intensive care unit at a tertiary referral hospital. Characteristics of premature infants with and without corneal haze were analyzed by correlation tests, Chi-square tests, and logistic regressions were used for statistical analyses. Associations between corneal haze and birth weight (BW), gestational age at birth (GA), central corneal thickness, intraocular pressure, and other systemic and ophthalmic data were evaluated.
The incidence of corneal haze was 13.4%. Lower BW, lower GA, packed red blood cells (RBC) transfusion, more days on oxygen, older maternal age, bronchopulmonary disease, and stage 3 ROP are associated with corneal haze. The severity of corneal haze decreased with infants' postmenstrual age. Multivariate logistic regression analyses revealed that BW and maternal age are the most important predictors of corneal haze.
Low BW and older maternal age are the most important predictors of corneal haze in premature infants. Premature infants with corneal haze could carry more systemic and ocular morbidities. Hence they may require more clinical attention. Corneal haze is unlikely to hinder the treatment of ROP. However, it is possible that corneal haze could hinder the examination of ROP in some infants. If corneal haze does interfere with ROP screening, a closer, more conservative follow-up schedule with a senior ophthalmologist experienced in managing ROP is recommended. |
| doi_str_mv | 10.1371/journal.pone.0195300 |
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To study associated factors of transient corneal haze in premature infants.
We performed a retrospective study of 261 premature infants from retinopathy of prematurity (ROP) screening in the neonatal intensive care unit at a tertiary referral hospital. Characteristics of premature infants with and without corneal haze were analyzed by correlation tests, Chi-square tests, and logistic regressions were used for statistical analyses. Associations between corneal haze and birth weight (BW), gestational age at birth (GA), central corneal thickness, intraocular pressure, and other systemic and ophthalmic data were evaluated.
The incidence of corneal haze was 13.4%. Lower BW, lower GA, packed red blood cells (RBC) transfusion, more days on oxygen, older maternal age, bronchopulmonary disease, and stage 3 ROP are associated with corneal haze. The severity of corneal haze decreased with infants' postmenstrual age. Multivariate logistic regression analyses revealed that BW and maternal age are the most important predictors of corneal haze.
Low BW and older maternal age are the most important predictors of corneal haze in premature infants. Premature infants with corneal haze could carry more systemic and ocular morbidities. Hence they may require more clinical attention. Corneal haze is unlikely to hinder the treatment of ROP. However, it is possible that corneal haze could hinder the examination of ROP in some infants. If corneal haze does interfere with ROP screening, a closer, more conservative follow-up schedule with a senior ophthalmologist experienced in managing ROP is recommended.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0195300</identifier><identifier>PMID: 29596534</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Analysis ; Biology and Life Sciences ; Birth weight ; Blood cells ; Blood transfusion ; Cataracts ; Congenital diseases ; Cornea ; Corneal diseases ; Correlation analysis ; Diagnosis ; Diseases and pests ; Erythrocytes ; Etiology ; Eye surgery ; Gestational age ; Health screening ; Hospitals ; Infants ; Intraocular pressure ; Medical examination ; Medical records ; Medicine ; Medicine and Health Sciences ; Neonates ; Newborn babies ; Oxygen ; Pediatrics ; People and Places ; Physical Sciences ; Premature babies ; Premature infants ; Regression analysis ; Retinopathy ; Risk factors ; Screening ; Statistical analysis ; Statistical tests ; Transfusion</subject><ispartof>PloS one, 2018-03, Vol.13 (3), p.e0195300-e0195300</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Lai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Lai et al 2018 Lai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3e86fd24cff9f6969eda126a48c8b4dd2c438c7518817867020e230870c181c23</citedby><cites>FETCH-LOGICAL-c692t-3e86fd24cff9f6969eda126a48c8b4dd2c438c7518817867020e230870c181c23</cites><orcidid>0000-0003-1997-0587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875869/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875869/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29596534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Yu-Hung</creatorcontrib><creatorcontrib>Chen, Hsiu-Lin</creatorcontrib><creatorcontrib>Yang, San-Nan</creatorcontrib><creatorcontrib>Chang, Shun-Jen</creatorcontrib><creatorcontrib>Chuang, Lea-Yea</creatorcontrib><creatorcontrib>Wu, Wen-Chuan</creatorcontrib><title>The characteristics of premature infants with transient corneal haze</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The etiology of transient corneal haze in premature infants is not known and how it relates to clinical outcomes in premature infants is not clear.
To study associated factors of transient corneal haze in premature infants.
We performed a retrospective study of 261 premature infants from retinopathy of prematurity (ROP) screening in the neonatal intensive care unit at a tertiary referral hospital. Characteristics of premature infants with and without corneal haze were analyzed by correlation tests, Chi-square tests, and logistic regressions were used for statistical analyses. Associations between corneal haze and birth weight (BW), gestational age at birth (GA), central corneal thickness, intraocular pressure, and other systemic and ophthalmic data were evaluated.
The incidence of corneal haze was 13.4%. Lower BW, lower GA, packed red blood cells (RBC) transfusion, more days on oxygen, older maternal age, bronchopulmonary disease, and stage 3 ROP are associated with corneal haze. The severity of corneal haze decreased with infants' postmenstrual age. Multivariate logistic regression analyses revealed that BW and maternal age are the most important predictors of corneal haze.
Low BW and older maternal age are the most important predictors of corneal haze in premature infants. Premature infants with corneal haze could carry more systemic and ocular morbidities. Hence they may require more clinical attention. Corneal haze is unlikely to hinder the treatment of ROP. However, it is possible that corneal haze could hinder the examination of ROP in some infants. If corneal haze does interfere with ROP screening, a closer, more conservative follow-up schedule with a senior ophthalmologist experienced in managing ROP is recommended.</description><subject>Age</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Blood cells</subject><subject>Blood transfusion</subject><subject>Cataracts</subject><subject>Congenital diseases</subject><subject>Cornea</subject><subject>Corneal diseases</subject><subject>Correlation analysis</subject><subject>Diagnosis</subject><subject>Diseases and pests</subject><subject>Erythrocytes</subject><subject>Etiology</subject><subject>Eye surgery</subject><subject>Gestational age</subject><subject>Health screening</subject><subject>Hospitals</subject><subject>Infants</subject><subject>Intraocular pressure</subject><subject>Medical examination</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Oxygen</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Premature babies</subject><subject>Premature infants</subject><subject>Regression analysis</subject><subject>Retinopathy</subject><subject>Risk factors</subject><subject>Screening</subject><subject>Statistical analysis</subject><subject>Statistical 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characteristics of premature infants with transient corneal haze</title><author>Lai, Yu-Hung ; Chen, Hsiu-Lin ; Yang, San-Nan ; Chang, Shun-Jen ; Chuang, Lea-Yea ; Wu, Wen-Chuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3e86fd24cff9f6969eda126a48c8b4dd2c438c7518817867020e230870c181c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Blood cells</topic><topic>Blood transfusion</topic><topic>Cataracts</topic><topic>Congenital diseases</topic><topic>Cornea</topic><topic>Corneal diseases</topic><topic>Correlation analysis</topic><topic>Diagnosis</topic><topic>Diseases and pests</topic><topic>Erythrocytes</topic><topic>Etiology</topic><topic>Eye surgery</topic><topic>Gestational age</topic><topic>Health 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One</addtitle><date>2018-03-29</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>e0195300</spage><epage>e0195300</epage><pages>e0195300-e0195300</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The etiology of transient corneal haze in premature infants is not known and how it relates to clinical outcomes in premature infants is not clear.
To study associated factors of transient corneal haze in premature infants.
We performed a retrospective study of 261 premature infants from retinopathy of prematurity (ROP) screening in the neonatal intensive care unit at a tertiary referral hospital. Characteristics of premature infants with and without corneal haze were analyzed by correlation tests, Chi-square tests, and logistic regressions were used for statistical analyses. Associations between corneal haze and birth weight (BW), gestational age at birth (GA), central corneal thickness, intraocular pressure, and other systemic and ophthalmic data were evaluated.
The incidence of corneal haze was 13.4%. Lower BW, lower GA, packed red blood cells (RBC) transfusion, more days on oxygen, older maternal age, bronchopulmonary disease, and stage 3 ROP are associated with corneal haze. The severity of corneal haze decreased with infants' postmenstrual age. Multivariate logistic regression analyses revealed that BW and maternal age are the most important predictors of corneal haze.
Low BW and older maternal age are the most important predictors of corneal haze in premature infants. Premature infants with corneal haze could carry more systemic and ocular morbidities. Hence they may require more clinical attention. Corneal haze is unlikely to hinder the treatment of ROP. However, it is possible that corneal haze could hinder the examination of ROP in some infants. If corneal haze does interfere with ROP screening, a closer, more conservative follow-up schedule with a senior ophthalmologist experienced in managing ROP is recommended.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29596534</pmid><doi>10.1371/journal.pone.0195300</doi><orcidid>https://orcid.org/0000-0003-1997-0587</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Age Analysis Biology and Life Sciences Birth weight Blood cells Blood transfusion Cataracts Congenital diseases Cornea Corneal diseases Correlation analysis Diagnosis Diseases and pests Erythrocytes Etiology Eye surgery Gestational age Health screening Hospitals Infants Intraocular pressure Medical examination Medical records Medicine Medicine and Health Sciences Neonates Newborn babies Oxygen Pediatrics People and Places Physical Sciences Premature babies Premature infants Regression analysis Retinopathy Risk factors Screening Statistical analysis Statistical tests Transfusion |
| title | The characteristics of premature infants with transient corneal haze |
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