Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors

Therapeutic options for the treatment of an increasing variety of cancers have been expanded by the introduction of a new class of drugs, commonly referred to as checkpoint blocking agents, that target the host immune system to positively modulate anti-tumor immune response. Although efficacy of the...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0179726-e0179726
Hauptverfasser:	Siemers, Nathan O, Holloway, James L, Chang, Han, Chasalow, Scott D, Ross-MacDonald, Petra B, Voliva, Charles F, Szustakowski, Joseph D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antigens Association analysis Beta cells Bioinformatics Biology and Life Sciences Biomarkers, Tumor - genetics Cancer Cancer treatment Care and treatment CD8-Positive T-Lymphocytes - immunology Cell death Chromosome 9 Chromosomes, Human, Pair 9 - genetics Copy number Correlation analysis Cytotoxicity Data analysis Diagnosis Fibroblast growth factor receptors Gene Dosage Genes Genetic analysis Genetic aspects Genetics Genome-wide association studies Genome-Wide Association Study Genomes Head & neck cancer Head and Neck Neoplasms - genetics Head and neck tumors Humans Immune checkpoint Immune response Immune system Immunology Immunosuppressive agents Infiltration Interferon Internet Lymphocytes Macrophages Medical prognosis Medicine and Health Sciences Melanoma Metastases Monocytes Mutation Mutation - genetics Natural killer cells Neck Neoplasm Proteins - genetics Neoplasms - genetics Neoplasms - immunology p53 Protein Pancreas Pathways Patients Raf protein Regulators Sequence Analysis, RNA Solid tumors Transcription Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumors
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