Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression

Fibrinogen, 1 of 13 coagulation factors responsible for normal blood clotting, is synthesized by hepatocytes. Detailed roles of the orphan nuclear receptors regulating fibrinogen gene expression have not yet been fully elucidated. Here, we identified estrogen-related receptor gamma (ERRγ) as a novel...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0182141-e0182141
Hauptverfasser:	Zhang, Yaochen, Kim, Don-Kyu, Lu, Yan, Jung, Yoon Seok, Lee, Ji-Min, Kim, Young-Hoon, Lee, Yong Soo, Kim, Jina, Dewidar, Bedair, Jeong, Won-Il, Lee, In-Kyu, Cho, Sung Jin, Dooley, Steven, Lee, Chul-Ho, Li, Xiaoying, Choi, Hueng-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Binding sites Biology and Life Sciences Blood clots Blood coagulation Cannabinoid CB1 receptors Cell culture Clonal deletion Clotting Coagulation Conservation Diabetes Endocrinology Estrogens Fibrinogen Fibrinogen - genetics Fibrinogen - metabolism Gene deletion Gene expression Gene Expression Regulation Gene Knockdown Techniques Hep G2 Cells Hepatocytes Hepatoma Hospitals Humans Insulin Kinases Laboratories Ligands Liver Liver - metabolism Liver diseases Medicine Medicine and Health Sciences Metabolic disorders Mice Middle Aged Non-alcoholic Fatty Liver Disease - genetics Nuclear receptors Obesity Obesity - genetics Orphan nuclear receptors Phosphatase Promoter Regions, Genetic - genetics R&D Receptor, Cannabinoid, CB1 - metabolism Receptors Receptors, Estrogen - metabolism Research & development Research and Analysis Methods Rodents Signaling Transcription Transcription, Genetic
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