Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis
We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC). We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnos...
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| Veröffentlicht in: | PloS one 2017-07, Vol.12 (7), p.e0182117-e0182117 |
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| description | We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC).
We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.
The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA) was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2) were: sensitivity 38% (95% CI 0.35-0.40), specificity 89% (95% CI 0.86-0.91), diagnostic accuracy 65.9% (range 62.5-81.8%), AUC 0.52 (0.48-0.57), while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D) were: sensitivity 47% (95% CI 0.34-0.60), specificity 90% (95% CI 0.89-0.92), diagnostic accuracy 78.4% (range 67.5-88.8%), AUC 0.90 (0.87-0.93). For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively.
Serum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which may be used as potential biomarkers for the early detection of LC. |
| doi_str_mv | 10.1371/journal.pone.0182117 |
| format | Article |
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We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.
The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA) was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2) were: sensitivity 38% (95% CI 0.35-0.40), specificity 89% (95% CI 0.86-0.91), diagnostic accuracy 65.9% (range 62.5-81.8%), AUC 0.52 (0.48-0.57), while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D) were: sensitivity 47% (95% CI 0.34-0.60), specificity 90% (95% CI 0.89-0.92), diagnostic accuracy 78.4% (range 67.5-88.8%), AUC 0.90 (0.87-0.93). For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively.
Serum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which may be used as potential biomarkers for the early detection of LC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0182117</identifier><identifier>PMID: 28750095</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antigens ; Autoantibodies ; Autoantibodies - blood ; Autoantibodies - immunology ; Autoantibodies - isolation & purification ; Bioindicators ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers, Tumor - blood ; Blood tests ; Cages ; Cancer ; Cancer therapies ; Diagnosis ; Diagnostic systems ; Disease ; Enzyme-linked immunosorbent assay ; Hospitals ; Humans ; Immunoglobulins ; Lung cancer ; Lung diseases ; Lung Neoplasms - blood ; Lung Neoplasms - diagnosis ; Lung Neoplasms - immunology ; Lung Neoplasms - pathology ; Medical diagnosis ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; Mortality ; Multiplexing ; Neoplasm Staging ; p53 Protein ; Patients ; Physical Sciences ; Publication Bias ; Research and Analysis Methods ; Respiratory diseases ; ROC Curve ; Sensitivity ; Sensitivity analysis ; Sensitivity and Specificity ; Studies ; Systematic review</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0182117-e0182117</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Tang et al 2017 Tang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-9f933ae58cfedee55d5deb8083d78ec3bb60e7f183c19cfe26500ec50dd42e1a3</citedby><cites>FETCH-LOGICAL-c758t-9f933ae58cfedee55d5deb8083d78ec3bb60e7f183c19cfe26500ec50dd42e1a3</cites><orcidid>0000-0001-5174-5262</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547718/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547718/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28750095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>De Re, Valli</contributor><creatorcontrib>Tang, Zhen-Ming</creatorcontrib><creatorcontrib>Ling, Zhou-Gui</creatorcontrib><creatorcontrib>Wang, Chun-Mei</creatorcontrib><creatorcontrib>Wu, Yan-Bin</creatorcontrib><creatorcontrib>Kong, Jin-Liang</creatorcontrib><title>Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC).
We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.
The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA) was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2) were: sensitivity 38% (95% CI 0.35-0.40), specificity 89% (95% CI 0.86-0.91), diagnostic accuracy 65.9% (range 62.5-81.8%), AUC 0.52 (0.48-0.57), while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D) were: sensitivity 47% (95% CI 0.34-0.60), specificity 90% (95% CI 0.89-0.92), diagnostic accuracy 78.4% (range 67.5-88.8%), AUC 0.90 (0.87-0.93). For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively.
Serum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which may be used as potential biomarkers for the early detection of LC.</description><subject>Antigens</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Autoantibodies - isolation & purification</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Blood tests</subject><subject>Cages</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - immunology</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Multiplexing</subject><subject>Neoplasm Staging</subject><subject>p53 Protein</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Publication Bias</subject><subject>Research and Analysis Methods</subject><subject>Respiratory diseases</subject><subject>ROC Curve</subject><subject>Sensitivity</subject><subject>Sensitivity analysis</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QLguhFx6Rp-uGFsCx-DCwsuOptOE1OOxnbZjZJV-ffm3G6y1T2QnKRkDznPXlPcqLoOSVLygr6bmNGO0C33JoBl4SWKaXFg-iUVixN8pSwh0frk-iJcxtCOCvz_HF0kpYFJ6Tip9F4hXbsYz_2xibgnJEaPKoYRm9g8Lo2SqOLwcVKQzsY57WMa216sD_RurgxNu7GoY0lDBLt-_gsdjvnsYc9aPFG468YBhX36CGBcOGd0-5p9KiBzuGzaV5E3z99_Hb-Jbm4_Lw6P7tIZMFLn1RNxRggL2WDCpFzxRXWJSmZKkqUrK5zgkVDSyZpFZg0D65QcqJUliIFtoheHnS3nXFiqpgTKaEFT6siLQKxOhDKwEZsrQ7GdsKAFn83jG0F2GClQ1FyULwhdQ20zLCmdZ5m4SqUccabqsSg9WHKNtY9KomDt9DNROcng16L1twIzrOiCC4W0ZtJwJrrEZ0XvXYSuw4GNKMTtEqznGR5lgX01T_o_e4mqoVgQA-NCXnlXlScZVUVxHhKA7W8hwpDYa9l-F6NDvuzgLezgMB4_O1bGJ0Tq6uv_89e_pizr4_YNULn1850o9dmcHMwO4DSGucsNndFpkTsu-O2GmLfHWLqjhD24viB7oJu24H9AXe1DHk</recordid><startdate>20170727</startdate><enddate>20170727</enddate><creator>Tang, Zhen-Ming</creator><creator>Ling, Zhou-Gui</creator><creator>Wang, Chun-Mei</creator><creator>Wu, Yan-Bin</creator><creator>Kong, Jin-Liang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5174-5262</orcidid></search><sort><creationdate>20170727</creationdate><title>Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis</title><author>Tang, Zhen-Ming ; Ling, Zhou-Gui ; Wang, Chun-Mei ; Wu, Yan-Bin ; Kong, Jin-Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-9f933ae58cfedee55d5deb8083d78ec3bb60e7f183c19cfe26500ec50dd42e1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antigens</topic><topic>Autoantibodies</topic><topic>Autoantibodies - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Zhen-Ming</au><au>Ling, Zhou-Gui</au><au>Wang, Chun-Mei</au><au>Wu, Yan-Bin</au><au>Kong, Jin-Liang</au><au>De Re, Valli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-07-27</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0182117</spage><epage>e0182117</epage><pages>e0182117-e0182117</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC).
We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.
The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA) was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2) were: sensitivity 38% (95% CI 0.35-0.40), specificity 89% (95% CI 0.86-0.91), diagnostic accuracy 65.9% (range 62.5-81.8%), AUC 0.52 (0.48-0.57), while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D) were: sensitivity 47% (95% CI 0.34-0.60), specificity 90% (95% CI 0.89-0.92), diagnostic accuracy 78.4% (range 67.5-88.8%), AUC 0.90 (0.87-0.93). For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively.
Serum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which may be used as potential biomarkers for the early detection of LC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28750095</pmid><doi>10.1371/journal.pone.0182117</doi><tpages>e0182117</tpages><orcidid>https://orcid.org/0000-0001-5174-5262</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-07, Vol.12 (7), p.e0182117-e0182117 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2017529727 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antigens Autoantibodies Autoantibodies - blood Autoantibodies - immunology Autoantibodies - isolation & purification Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers, Tumor - blood Blood tests Cages Cancer Cancer therapies Diagnosis Diagnostic systems Disease Enzyme-linked immunosorbent assay Hospitals Humans Immunoglobulins Lung cancer Lung diseases Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - immunology Lung Neoplasms - pathology Medical diagnosis Medicine Medicine and Health Sciences Meta-analysis Mortality Multiplexing Neoplasm Staging p53 Protein Patients Physical Sciences Publication Bias Research and Analysis Methods Respiratory diseases ROC Curve Sensitivity Sensitivity analysis Sensitivity and Specificity Studies Systematic review |
| title | Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T08%3A53%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20tumor-associated%20autoantibodies%20as%20diagnostic%20biomarkers%20for%20lung%20cancer:%20A%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Tang,%20Zhen-Ming&rft.date=2017-07-27&rft.volume=12&rft.issue=7&rft.spage=e0182117&rft.epage=e0182117&rft.pages=e0182117-e0182117&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0182117&rft_dat=%3Cgale_plos_%3EA499460521%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2017529727&rft_id=info:pmid/28750095&rft_galeid=A499460521&rft_doaj_id=oai_doaj_org_article_85ad5f0bba184eb1b62408313535f98e&rfr_iscdi=true |