CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway

Cultivating an environment of mutualism between host cells and the microbiota is vital, and dysregulation of this relationship is associated with multiple immune disorders including metabolic and skin diseases, asthma, allergy, and Inflammatory Bowel Disease (IBD). One prominent mechanism for mainta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0181866
Hauptverfasser:	Alexander, Katie L, Katz, Jannet, Elson, Charles O
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals Anti-inflammatory agents Antigen presentation Antigen-Presenting Cells - metabolism Antigens Asthma B-Lymphocytes - immunology Biology and Life Sciences CD4 antigen Cell Line Cell survival Cholera Cholera toxin Cholera Toxin - metabolism Cholera toxin B subunit Cytokines Dendritic cells Dendritic Cells - immunology Diabetes Epitopes - immunology Flagellin Flagellin - agonists Forkhead Transcription Factors - metabolism Foxp3 protein Fusion protein Genomics Health aspects Homeostasis Hypersensitivity Immunoglobulin A Immunoglobulin A - immunology Immunology Infections Inflammation Inflammatory bowel diseases Intestine Intestines Lymphocytes Lymphocytes B Lymphocytes T Medicine and Health Sciences Metabolism Mice, Inbred C57BL Microbiota Mutualism Neutralization Physiological aspects Proteins Public health Rapamycin Recombinant Fusion Proteins - metabolism Regulation Research and Analysis Methods Retinoic acid Signal Transduction Signaling Skin diseases T cell receptors T cells T-Lymphocytes, Regulatory - immunology TOR protein TOR Serine-Threonine Kinases - metabolism Toxin b Toxins Transforming Growth Factor beta - metabolism Transplants & implants Tretinoin - metabolism Vibrio cholerae Water-borne diseases Waterborne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!