Deferoxamine therapy for intracerebral hemorrhage: A systematic review
Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide. Several recent controlled trials have reported that deferoxamine (DFX) therapy appears to be effective for ICH. The aim of this study was to perform a systematic review of DFX therapy for ICH patients and eva...
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| creator | Zeng, Liling Tan, Li Li, Haijun Zhang, Qixin Li, Yongxian Guo, Jianwen |
| description | Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide. Several recent controlled trials have reported that deferoxamine (DFX) therapy appears to be effective for ICH. The aim of this study was to perform a systematic review of DFX therapy for ICH patients and evaluate the efficacy and safety of DFX therapy for ICH patients. We searched Medline, Embase, the Cochrane Database of Systematic Reviews, clinicaltrials.gov, all Chinese databases and the reference lists of all included studies and review articles. We then performed a systematic review of studies involving the administration of DFX following ICH. Only two studies were included, a prospective, randomized clinical trial and a prospective,observational cohort study with concurrent groups. Qualitative analysis of each study revealed one randomized controlled trial of moderate quality with a moderate risk of bias and one observational cohort study of moderate quality with a moderate risk of bias. DFX may be an effective treatment for edema in patients with ICH. However, due to the small number of trials and small sample sizes of these trials, insufficient evidence exists to determine the effect of DFX on neurologic outcomes after ICH and the safety of this intervention. Further investigation is required before DFX can become a routine treatment for ICH. |
| doi_str_mv | 10.1371/journal.pone.0193615 |
| format | Article |
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Several recent controlled trials have reported that deferoxamine (DFX) therapy appears to be effective for ICH. The aim of this study was to perform a systematic review of DFX therapy for ICH patients and evaluate the efficacy and safety of DFX therapy for ICH patients. We searched Medline, Embase, the Cochrane Database of Systematic Reviews, clinicaltrials.gov, all Chinese databases and the reference lists of all included studies and review articles. We then performed a systematic review of studies involving the administration of DFX following ICH. Only two studies were included, a prospective, randomized clinical trial and a prospective,observational cohort study with concurrent groups. Qualitative analysis of each study revealed one randomized controlled trial of moderate quality with a moderate risk of bias and one observational cohort study of moderate quality with a moderate risk of bias. DFX may be an effective treatment for edema in patients with ICH. However, due to the small number of trials and small sample sizes of these trials, insufficient evidence exists to determine the effect of DFX on neurologic outcomes after ICH and the safety of this intervention. Further investigation is required before DFX can become a routine treatment for ICH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0193615</identifier><identifier>PMID: 29566000</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Bias ; Biology and Life Sciences ; Brain research ; Care and treatment ; Cerebral Hemorrhage - drug therapy ; Citation management software ; Clinical trials ; Cohort analysis ; Complications and side effects ; Deferoxamine ; Deferoxamine - adverse effects ; Deferoxamine - pharmacology ; Deferoxamine - therapeutic use ; Dosage and administration ; Drug therapy ; Edema ; Emergency medical care ; Health aspects ; Hemorrhage ; Humans ; Intracerebral hemorrhage ; Laboratories ; Literature reviews ; Medicine ; Medicine and Health Sciences ; Morbidity ; Mortality ; Neurology ; Patient outcomes ; Patients ; Qualitative analysis ; Research and Analysis Methods ; Safety ; Stroke ; Studies ; Systematic review ; Teaching hospitals ; Therapy ; Traumatic brain injury</subject><ispartof>PloS one, 2018-03, Vol.13 (3), p.e0193615-e0193615</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Zeng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Zeng et al 2018 Zeng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-25da62e4214d098a8dd0c25f15191b08b9c19e7223ea54d49b43e6914f24251e3</citedby><cites>FETCH-LOGICAL-c692t-25da62e4214d098a8dd0c25f15191b08b9c19e7223ea54d49b43e6914f24251e3</cites><orcidid>0000-0001-5876-2807</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863956/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863956/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29566000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Liling</creatorcontrib><creatorcontrib>Tan, Li</creatorcontrib><creatorcontrib>Li, Haijun</creatorcontrib><creatorcontrib>Zhang, Qixin</creatorcontrib><creatorcontrib>Li, Yongxian</creatorcontrib><creatorcontrib>Guo, Jianwen</creatorcontrib><title>Deferoxamine therapy for intracerebral hemorrhage: A systematic review</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide. Several recent controlled trials have reported that deferoxamine (DFX) therapy appears to be effective for ICH. The aim of this study was to perform a systematic review of DFX therapy for ICH patients and evaluate the efficacy and safety of DFX therapy for ICH patients. We searched Medline, Embase, the Cochrane Database of Systematic Reviews, clinicaltrials.gov, all Chinese databases and the reference lists of all included studies and review articles. We then performed a systematic review of studies involving the administration of DFX following ICH. Only two studies were included, a prospective, randomized clinical trial and a prospective,observational cohort study with concurrent groups. Qualitative analysis of each study revealed one randomized controlled trial of moderate quality with a moderate risk of bias and one observational cohort study of moderate quality with a moderate risk of bias. DFX may be an effective treatment for edema in patients with ICH. However, due to the small number of trials and small sample sizes of these trials, insufficient evidence exists to determine the effect of DFX on neurologic outcomes after ICH and the safety of this intervention. Further investigation is required before DFX can become a routine treatment for ICH.</description><subject>Analysis</subject><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Brain research</subject><subject>Care and treatment</subject><subject>Cerebral Hemorrhage - drug therapy</subject><subject>Citation management software</subject><subject>Clinical trials</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Deferoxamine</subject><subject>Deferoxamine - adverse effects</subject><subject>Deferoxamine - pharmacology</subject><subject>Deferoxamine - therapeutic use</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Edema</subject><subject>Emergency medical care</subject><subject>Health aspects</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Intracerebral hemorrhage</subject><subject>Laboratories</subject><subject>Literature 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Jianwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deferoxamine therapy for intracerebral hemorrhage: A systematic review</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-03-22</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>e0193615</spage><epage>e0193615</epage><pages>e0193615-e0193615</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide. Several recent controlled trials have reported that deferoxamine (DFX) therapy appears to be effective for ICH. The aim of this study was to perform a systematic review of DFX therapy for ICH patients and evaluate the efficacy and safety of DFX therapy for ICH patients. We searched Medline, Embase, the Cochrane Database of Systematic Reviews, clinicaltrials.gov, all Chinese databases and the reference lists of all included studies and review articles. We then performed a systematic review of studies involving the administration of DFX following ICH. Only two studies were included, a prospective, randomized clinical trial and a prospective,observational cohort study with concurrent groups. Qualitative analysis of each study revealed one randomized controlled trial of moderate quality with a moderate risk of bias and one observational cohort study of moderate quality with a moderate risk of bias. DFX may be an effective treatment for edema in patients with ICH. However, due to the small number of trials and small sample sizes of these trials, insufficient evidence exists to determine the effect of DFX on neurologic outcomes after ICH and the safety of this intervention. Further investigation is required before DFX can become a routine treatment for ICH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29566000</pmid><doi>10.1371/journal.pone.0193615</doi><tpages>e0193615</tpages><orcidid>https://orcid.org/0000-0001-5876-2807</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Bias Biology and Life Sciences Brain research Care and treatment Cerebral Hemorrhage - drug therapy Citation management software Clinical trials Cohort analysis Complications and side effects Deferoxamine Deferoxamine - adverse effects Deferoxamine - pharmacology Deferoxamine - therapeutic use Dosage and administration Drug therapy Edema Emergency medical care Health aspects Hemorrhage Humans Intracerebral hemorrhage Laboratories Literature reviews Medicine Medicine and Health Sciences Morbidity Mortality Neurology Patient outcomes Patients Qualitative analysis Research and Analysis Methods Safety Stroke Studies Systematic review Teaching hospitals Therapy Traumatic brain injury |
| title | Deferoxamine therapy for intracerebral hemorrhage: A systematic review |
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