Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery
To determine whether pre-treatment growth rate of vestibular schwannomas (VS) predict response to radiosurgery. A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Lekse...
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| description | To determine whether pre-treatment growth rate of vestibular schwannomas (VS) predict response to radiosurgery.
A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.
Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).
Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE. |
| doi_str_mv | 10.1371/journal.pone.0110823 |
| format | Article |
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A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.
Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).
Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0110823</identifier><identifier>PMID: 25337892</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Brain cancer ; Care and treatment ; Complications ; Complications and side effects ; Correlation ; Dosimetry ; Female ; Growth ; Growth rate ; Health care networks ; Humans ; Incidence ; Itk protein ; Magnetic resonance imaging ; Male ; Measurement techniques ; Medicine and Health Sciences ; Middle Aged ; Neuroma, Acoustic - pathology ; Neuroma, Acoustic - secondary ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Patients ; Pretreatment ; Radiation ; Radiation (Physics) ; Radiation effects ; Radiation Injuries - epidemiology ; Radiation therapy ; Radiology ; Radiosurgery ; Radiosurgery - adverse effects ; Retrospective Studies ; Risk analysis ; Risk factors ; Statistical analysis ; Surgery ; Treatment Outcome ; Tumor Burden ; Tumors ; Vestibular system</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e110823</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Larjani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Larjani et al 2014 Larjani et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9f53b5294af6a1b8d7173211a952b4fba6c5258784344381f53e0cde056a7ca73</citedby><cites>FETCH-LOGICAL-c692t-9f53b5294af6a1b8d7173211a952b4fba6c5258784344381f53e0cde056a7ca73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206429/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206429/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25337892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kozak, Kevin Robert</contributor><creatorcontrib>Larjani, Soroush</creatorcontrib><creatorcontrib>Monsalves, Eric</creatorcontrib><creatorcontrib>Pebdani, Houman</creatorcontrib><creatorcontrib>Krischek, Boris</creatorcontrib><creatorcontrib>Gentili, Fred</creatorcontrib><creatorcontrib>Cusimano, Michael</creatorcontrib><creatorcontrib>Laperriere, Normand</creatorcontrib><creatorcontrib>Hayhurst, Caroline</creatorcontrib><creatorcontrib>Zadeh, Gelareh</creatorcontrib><title>Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine whether pre-treatment growth rate of vestibular schwannomas (VS) predict response to radiosurgery.
A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.
Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).
Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain cancer</subject><subject>Care and treatment</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Correlation</subject><subject>Dosimetry</subject><subject>Female</subject><subject>Growth</subject><subject>Growth rate</subject><subject>Health care networks</subject><subject>Humans</subject><subject>Incidence</subject><subject>Itk protein</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Measurement techniques</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Neuroma, Acoustic - pathology</subject><subject>Neuroma, Acoustic - secondary</subject><subject>Neurosurgery</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Pretreatment</subject><subject>Radiation</subject><subject>Radiation (Physics)</subject><subject>Radiation effects</subject><subject>Radiation Injuries - epidemiology</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Radiosurgery</subject><subject>Radiosurgery - adverse effects</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Vestibular system</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNktuLEzEYxQdR3HX1PxAdEAQfWnObzMyLsCxeCgsL3l7DN7lMU6aTmmRa-9-btrNLBxQkDwnJ75x8HE6WvcRojmmJ36_c4Hvo5hvX6znCGFWEPsoucU3JjBNEH5-dL7JnIawQKmjF-dPsghSUllVNLrPdQuk-WrO3fZtvvFZWRudD7kyuwXf7vPVuF5e51yF9FHQOvcpBbbVPZw_KQrSuz7UxWsajbKtDtM3Qgc-DXO6g790aQh7dEXdh8K32--fZEwNd0C_G_Sr78enj95svs9u7z4ub69uZ5DWJs9oUtClIzcBwwE2lSlxSgjHUBWmYaYDLghRVWTHKGK1wwjWSSqOCQymhpFfZ65PvpnNBjJkFQRBmJcO8IIlYnAjlYCU23q7B74UDK44XzrcCfLSy04JqRSUhFRBUMiVxbao0myJKY14XnCevD-NvQ7PWSqZoPXQT0-lLb5eidVvBCOKM1MngzWjg3a8hJfmPkUeqhTSV7Y1LZnJtgxTXDFeYcFYehpn_hUpL6bWVqTXGpvuJ4N1EkJiof8cWhhDE4tvX_2fvfk7Zt2fsUkMXl8F1w6E5YQqyEyi9C8Fr85AcRuJQ-vs0xKH0Yix9kr06T_1BdN9y-gcsPP46</recordid><startdate>20141022</startdate><enddate>20141022</enddate><creator>Larjani, Soroush</creator><creator>Monsalves, Eric</creator><creator>Pebdani, Houman</creator><creator>Krischek, Boris</creator><creator>Gentili, Fred</creator><creator>Cusimano, Michael</creator><creator>Laperriere, Normand</creator><creator>Hayhurst, Caroline</creator><creator>Zadeh, Gelareh</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141022</creationdate><title>Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery</title><author>Larjani, Soroush ; Monsalves, Eric ; Pebdani, Houman ; Krischek, Boris ; Gentili, Fred ; Cusimano, Michael ; Laperriere, Normand ; Hayhurst, Caroline ; Zadeh, Gelareh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9f53b5294af6a1b8d7173211a952b4fba6c5258784344381f53e0cde056a7ca73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain cancer</topic><topic>Care and treatment</topic><topic>Complications</topic><topic>Complications and side effects</topic><topic>Correlation</topic><topic>Dosimetry</topic><topic>Female</topic><topic>Growth</topic><topic>Growth rate</topic><topic>Health care networks</topic><topic>Humans</topic><topic>Incidence</topic><topic>Itk protein</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Measurement techniques</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Neuroma, Acoustic - 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A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.
Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).
Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25337892</pmid><doi>10.1371/journal.pone.0110823</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Aged, 80 and over Brain cancer Care and treatment Complications Complications and side effects Correlation Dosimetry Female Growth Growth rate Health care networks Humans Incidence Itk protein Magnetic resonance imaging Male Measurement techniques Medicine and Health Sciences Middle Aged Neuroma, Acoustic - pathology Neuroma, Acoustic - secondary Neurosurgery NMR Nuclear magnetic resonance Patients Pretreatment Radiation Radiation (Physics) Radiation effects Radiation Injuries - epidemiology Radiation therapy Radiology Radiosurgery Radiosurgery - adverse effects Retrospective Studies Risk analysis Risk factors Statistical analysis Surgery Treatment Outcome Tumor Burden Tumors Vestibular system |
| title | Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T11%3A13%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identifying%20predictors%20of%20early%20growth%20response%20and%20adverse%20radiation%20effects%20of%20vestibular%20schwannomas%20to%20radiosurgery&rft.jtitle=PloS%20one&rft.au=Larjani,%20Soroush&rft.date=2014-10-22&rft.volume=9&rft.issue=10&rft.spage=e110823&rft.pages=e110823-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0110823&rft_dat=%3Cgale_plos_%3EA418126476%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2014741652&rft_id=info:pmid/25337892&rft_galeid=A418126476&rft_doaj_id=oai_doaj_org_article_3ed3c228a2074dc19f8529d2de169566&rfr_iscdi=true |