STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana
Organ size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently...
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| Veröffentlicht in: | PLoS genetics 2018-02, Vol.14 (2), p.e1007218-e1007218 |
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| creator | Li, Na Liu, Zupei Wang, Zhibiao Ru, Licong Gonzalez, Nathalie Baekelandt, Alexandra Pauwels, Laurens Goossens, Alain Xu, Ran Zhu, Zhengge Inzé, Dirk Li, Yunhai |
| description | Organ size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size. |
| doi_str_mv | 10.1371/journal.pgen.1007218 |
| format | Article |
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Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1007218</identifier><identifier>PMID: 29401459</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Arabidopsis ; Arabidopsis thaliana ; Bioinformatics ; Biology and Life Sciences ; Biotechnology ; Cell growth ; Cell proliferation ; Cell size ; Chromosomes ; Cytochrome ; Developmental biology ; Engineering ; F-box protein ; Genetic aspects ; Genetics ; Kinases ; Laboratories ; Life Sciences ; Meristem ; Plant sciences ; Proteins ; Regulation ; Research and Analysis Methods ; Stem cells ; Transcription ; Vegetal Biology</subject><ispartof>PLoS genetics, 2018-02, Vol.14 (2), p.e1007218-e1007218</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: . PLoS Genet 14(2): e1007218. https://doi.org/10.1371/journal.pgen.1007218</rights><rights>Attribution</rights><rights>2018 Li et al 2018 Li et al</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: . PLoS Genet 14(2): e1007218. https://doi.org/10.1371/journal.pgen.1007218</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c760t-6689cd0b5508c0f0e5ae524c91b2d3d450a8f187cadceb6d293edb8f440d6d923</citedby><cites>FETCH-LOGICAL-c760t-6689cd0b5508c0f0e5ae524c91b2d3d450a8f187cadceb6d293edb8f440d6d923</cites><orcidid>0000-0002-3946-1758 ; 0000-0002-0221-9052 ; 0000-0003-0816-7115 ; 0000-0001-6924-8387 ; 0000-0002-1599-551X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814100/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814100/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29401459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02625191$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Qu, Li-Jia</contributor><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Liu, Zupei</creatorcontrib><creatorcontrib>Wang, Zhibiao</creatorcontrib><creatorcontrib>Ru, Licong</creatorcontrib><creatorcontrib>Gonzalez, Nathalie</creatorcontrib><creatorcontrib>Baekelandt, Alexandra</creatorcontrib><creatorcontrib>Pauwels, Laurens</creatorcontrib><creatorcontrib>Goossens, Alain</creatorcontrib><creatorcontrib>Xu, Ran</creatorcontrib><creatorcontrib>Zhu, Zhengge</creatorcontrib><creatorcontrib>Inzé, Dirk</creatorcontrib><creatorcontrib>Li, Yunhai</creatorcontrib><title>STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana</title><title>PLoS genetics</title><addtitle>PLoS Genet</addtitle><description>Organ size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size.</description><subject>Arabidopsis</subject><subject>Arabidopsis thaliana</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cell size</subject><subject>Chromosomes</subject><subject>Cytochrome</subject><subject>Developmental biology</subject><subject>Engineering</subject><subject>F-box protein</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Meristem</subject><subject>Plant sciences</subject><subject>Proteins</subject><subject>Regulation</subject><subject>Research and Analysis Methods</subject><subject>Stem 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APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana</title><author>Li, Na ; Liu, Zupei ; Wang, Zhibiao ; Ru, Licong ; Gonzalez, Nathalie ; Baekelandt, Alexandra ; Pauwels, Laurens ; Goossens, Alain ; Xu, Ran ; Zhu, Zhengge ; Inzé, Dirk ; Li, Yunhai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c760t-6689cd0b5508c0f0e5ae524c91b2d3d450a8f187cadceb6d293edb8f440d6d923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arabidopsis</topic><topic>Arabidopsis thaliana</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Biotechnology</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Cell size</topic><topic>Chromosomes</topic><topic>Cytochrome</topic><topic>Developmental biology</topic><topic>Engineering</topic><topic>F-box protein</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Meristem</topic><topic>Plant sciences</topic><topic>Proteins</topic><topic>Regulation</topic><topic>Research and Analysis Methods</topic><topic>Stem cells</topic><topic>Transcription</topic><topic>Vegetal Biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Liu, Zupei</creatorcontrib><creatorcontrib>Wang, Zhibiao</creatorcontrib><creatorcontrib>Ru, Licong</creatorcontrib><creatorcontrib>Gonzalez, Nathalie</creatorcontrib><creatorcontrib>Baekelandt, Alexandra</creatorcontrib><creatorcontrib>Pauwels, Laurens</creatorcontrib><creatorcontrib>Goossens, Alain</creatorcontrib><creatorcontrib>Xu, Ran</creatorcontrib><creatorcontrib>Zhu, Zhengge</creatorcontrib><creatorcontrib>Inzé, Dirk</creatorcontrib><creatorcontrib>Li, 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but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29401459</pmid><doi>10.1371/journal.pgen.1007218</doi><orcidid>https://orcid.org/0000-0002-3946-1758</orcidid><orcidid>https://orcid.org/0000-0002-0221-9052</orcidid><orcidid>https://orcid.org/0000-0003-0816-7115</orcidid><orcidid>https://orcid.org/0000-0001-6924-8387</orcidid><orcidid>https://orcid.org/0000-0002-1599-551X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis Arabidopsis thaliana Bioinformatics Biology and Life Sciences Biotechnology Cell growth Cell proliferation Cell size Chromosomes Cytochrome Developmental biology Engineering F-box protein Genetic aspects Genetics Kinases Laboratories Life Sciences Meristem Plant sciences Proteins Regulation Research and Analysis Methods Stem cells Transcription Vegetal Biology |
| title | STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana |
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