Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30

HIV-1-infected cells persist indefinitely despite the use of combination antiretroviral therapy (ART), and novel therapeutic strategies to target and purge residual infected cells in individuals on ART are urgently needed. Here, we demonstrate that CD4+ T cell-associated HIV-1 RNA is often highly en...

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Veröffentlicht in:	PLoS pathogens 2018-02, Vol.14 (2), p.e1006856
Hauptverfasser:	Hogan, Louise E, Vasquez, Joshua, Hobbs, Kristen S, Hanhauser, Emily, Aguilar-Rodriguez, Brandon, Hussien, Rajaa, Thanh, Cassandra, Gibson, Erica A, Carvidi, Alexander B, Smith, Louis C B, Khan, Shahzada, Trapecar, Martin, Sanjabi, Shomyseh, Somsouk, Ma, Stoddart, Cheryl A, Kuritzkes, Daniel R, Deeks, Steven G, Henrich, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Biology and Life Sciences Biomarkers - blood Biomarkers - metabolism Blood Brentuximab Vedotin CD30 antigen CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Cells, Cultured Cohort Studies Deoxyribonucleic acid DNA DNA, Viral - blood DNA, Viral - metabolism Drug therapy Gene expression Gut-associated lymphoid tissues HIV HIV Infections - drug therapy HIV Infections - metabolism HIV Infections - pathology HIV Infections - virology HIV-1 - drug effects HIV-1 - isolation & purification HIV-1 - pathogenicity HIV-1 - physiology Human immunodeficiency virus Humans Hybridization Immunoconjugates - pharmacology Immunology In Situ Hybridization Ki-1 Antigen - antagonists & inhibitors Ki-1 Antigen - blood Ki-1 Antigen - chemistry Ki-1 Antigen - metabolism Leukocytes (mononuclear) Localization Lymphocytes Lymphocytes T Lymphoid tissue Lymphoid Tissue - drug effects Lymphoid Tissue - metabolism Lymphoid Tissue - pathology Lymphoid Tissue - virology Lymphoma Medicine Medicine and Health Sciences Monoclonal antibodies Peripheral blood mononuclear cells Rectum - drug effects Rectum - metabolism Rectum - pathology Rectum - virology Research and Analysis Methods Ribonucleic acid RNA RNA, Viral - blood RNA, Viral - metabolism Solubility Supervision Targeted cancer therapy Therapeutic applications Tissues Transcription Transcriptional Activation - drug effects Viral Load - drug effects Virology Viruses
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