Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

The lack of a mutant phenotype in homozygous mutant individuals' due to compensatory gene expression triggered upstream of protein function has been identified as genetic compensation. Whilst this intriguing process has been recognized in zebrafish, the presence of homozygous loss of function m...

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Veröffentlicht in:	PLoS genetics 2018-02, Vol.14 (2), p.e1007212-e1007212
Hauptverfasser:	Sztal, Tamar E, McKaige, Emily A, Williams, Caitlin, Ruparelia, Avnika A, Bryson-Richardson, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Antisense RNA Biology and Life Sciences Compensation Danio rerio Funding Gene expression Gene mutation Genetic aspects Genomes Medicine and Health Sciences Muscle function Muscular diseases Muscular dystrophy Musculoskeletal system Mutation Myopathy Nemaline myopathy Phenotypes Physiological aspects Proteins Research and Analysis Methods Transcription Vertebrates Zebrafish
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