Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-β signaling

Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) secrete soluble factor TGF-β1 to support BBB integrity. Firstly, we prepared con...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e103174-e103174
Hauptverfasser:	Seo, Ji Hae, Maki, Takakuni, Maeda, Mitsuyo, Miyamoto, Nobukazu, Liang, Anna C, Hayakawa, Kazuhide, Pham, Loc-Duyen D, Suwa, Fumihiko, Taguchi, Akihiko, Matsuyama, Tomohiro, Ihara, Masafumi, Kim, Kyu-Won, Lo, Eng H, Arai, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Basal lamina Biology and Life Sciences Biomedical research Blood-Brain Barrier Brain research Conditioning Departments Endothelial cells Endothelium Flox Glial stem cells Growth factors Hemorrhage Hospitals Integrity Laboratory animals Medical schools Medicine Membrane permeability Mice Neonates Nervous system Neural Stem Cells - cytology Neurogenesis Neurology Oligodendroglia - cytology Penicillin Pericytes Permeability Pharmaceutical sciences Pharmacology Pharmacy Precursors Proteins Rats Rats, Sprague-Dawley Regulators Rodents Signal Transduction Signaling Stroke Tightness Transforming Growth Factor beta - metabolism Transforming growth factor-b1 Transgenic mice
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