The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial

The clinical utility of denosumab for the treatment of glucocorticoid-induced osteoporosis (GIOP) has yet to be established. This study aimed to compare the effects of denosumab on bone mineral density (BMD) and bone turnover markers to those of alendronate in patients with GIOP. A prospective, sing...

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Veröffentlicht in:	PloS one 2018-03, Vol.13 (3), p.e0193846
Hauptverfasser:	Iseri, Ken, Iyoda, Masayuki, Watanabe, Makoto, Matsumoto, Kei, Sanada, Daisuke, Inoue, Takashi, Tachibana, Shohei, Shibata, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase (tartrate-resistant) Adult Aged Alendronate Alendronate - adverse effects Alendronate - therapeutic use Alendronic acid Arthritis Biocompatibility Biology and Life Sciences Biomarkers - blood Bisphosphonates Bone density Bone Density Conservation Agents - adverse effects Bone Density Conservation Agents - therapeutic use Bone mineral density Bone Remodeling - drug effects Bone turnover Calcitriol Care and treatment Cholesterol Demographics Denosumab Denosumab - adverse effects Denosumab - therapeutic use Development and progression Disease Disease control Disease prevention Female Gene expression Glucocorticoids Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Health aspects Hospitals Humans Immunotherapy Kidney diseases Kidney Diseases - blood Kidney Diseases - complications Kidney Diseases - drug therapy Lumbar Vertebrae - drug effects Male Markers Medicine Medicine and Health Sciences Metabolism Middle Aged Monoclonal antibodies Nephrology Osteoporosis Osteoporosis - blood Osteoporosis - chemically induced Osteoporosis - drug therapy Patient outcomes Patients Phosphatase Physiological aspects Prednisolone Prednisolone - adverse effects Prednisolone - therapeutic use Randomization Research and Analysis Methods Serum levels Spine Spine (lumbar) Studies Transplants & implants Treatment Outcome Womens health
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