Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study
Associations between dopamine receptor levels and pro- and antisocial behavior have previously been demonstrated in human subjects using positron emission tomography (PET) and self-rated measures of personality traits. So far, only one study has focused on the dopamine D1-receptor (D1-R), finding a...
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| Veröffentlicht in: | PloS one 2018-03, Vol.13 (3), p.e0193770-e0193770 |
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| creator | Plavén-Sigray, Pontus Matheson, Granville James Gustavsson, Petter Stenkrona, Per Halldin, Christer Farde, Lars Cervenka, Simon |
| description | Associations between dopamine receptor levels and pro- and antisocial behavior have previously been demonstrated in human subjects using positron emission tomography (PET) and self-rated measures of personality traits. So far, only one study has focused on the dopamine D1-receptor (D1-R), finding a positive correlation with the trait social desirability, which is characterized by low dominant and high affiliative behavior, while physical aggression showed a negative correlation. The aim of the present study was to replicate these previous findings using a new independent sample of subjects.
Twenty-six healthy males were examined with the radioligand [11C]SCH-23390, and completed the Swedish universities Scales of Personality (SSP) which includes measures of social desirability and physical trait aggression. The simplified reference tissue model with cerebellum as reference region was used to calculate BPND values in the whole striatum and limbic striatum. The two regions were selected since they showed strong association between D1-R availability and personality scores in the previous study. Pearson's correlation coefficients and replication Bayes factors were then employed to assess the replicability and robustness of previous results.
There were no significant correlations (all p values > 0.3) between regional BPND values and personality scale scores. Replication Bayes factors showed strong to moderate evidence in favor no relationship between D1-receptor availability and social desirability (striatum BF01 = 12.4; limbic striatum BF01 = 7.2) or physical aggression scale scores (limbic striatum BF01 = 3.3), compared to the original correlations.
We could not replicate the previous findings of associations between D1-R availability and either pro- or antisocial behavior as measured using the SSP. Rather, there was evidence in favor of failed replications of associations between BPND and scale scores. Potential reasons for these results are restrictive variance in both PET and personality outcomes due to high sample homogeneity, or that the previous findings were false positives. |
| doi_str_mv | 10.1371/journal.pone.0193770 |
| format | Article |
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Twenty-six healthy males were examined with the radioligand [11C]SCH-23390, and completed the Swedish universities Scales of Personality (SSP) which includes measures of social desirability and physical trait aggression. The simplified reference tissue model with cerebellum as reference region was used to calculate BPND values in the whole striatum and limbic striatum. The two regions were selected since they showed strong association between D1-R availability and personality scores in the previous study. Pearson's correlation coefficients and replication Bayes factors were then employed to assess the replicability and robustness of previous results.
There were no significant correlations (all p values > 0.3) between regional BPND values and personality scale scores. Replication Bayes factors showed strong to moderate evidence in favor no relationship between D1-receptor availability and social desirability (striatum BF01 = 12.4; limbic striatum BF01 = 7.2) or physical aggression scale scores (limbic striatum BF01 = 3.3), compared to the original correlations.
We could not replicate the previous findings of associations between D1-R availability and either pro- or antisocial behavior as measured using the SSP. Rather, there was evidence in favor of failed replications of associations between BPND and scale scores. Potential reasons for these results are restrictive variance in both PET and personality outcomes due to high sample homogeneity, or that the previous findings were false positives.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0193770</identifier><identifier>PMID: 29543812</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aggression ; Aggression - physiology ; Aggressive behavior ; Aggressiveness ; Analysis ; Antisocial personality disorder ; Availability ; Bayes Theorem ; Bayesian analysis ; Benzazepines ; Biology and Life Sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Brain Mapping ; Brain research ; Carbon Radioisotopes ; Cerebellum ; Correlation ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Councils ; Dopamine ; Dopamine D1 receptors ; Dopamine receptors ; Emission analysis ; Emission measurements ; Emissions ; Homogeneity ; Human behavior ; Humans ; Magnetic Resonance Imaging ; Male ; Males ; Medical imaging ; Medical research ; Medical screening ; Medicin och hälsovetenskap ; Medicine and Health Sciences ; Neostriatum ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Personality ; Personality - physiology ; Personality Tests ; Personality traits ; Physical Sciences ; Positron emission ; Positron emission tomography ; Psychiatry ; Psychology ; Radiopharmaceuticals ; Receptors, Dopamine D1 - metabolism ; Replication ; Research and Analysis Methods ; Social Behavior ; Social Sciences ; Studies ; Tomography</subject><ispartof>PloS one, 2018-03, Vol.13 (3), p.e0193770-e0193770</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Plavén-Sigray et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Plavén-Sigray et al 2018 Plavén-Sigray et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c817t-559fbc71e1ccee114e90d19461cf8aaa3289c43baf80a70086831689caff5b3a3</citedby><cites>FETCH-LOGICAL-c817t-559fbc71e1ccee114e90d19461cf8aaa3289c43baf80a70086831689caff5b3a3</cites><orcidid>0000-0001-5342-5641</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854259/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854259/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,553,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29543812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440724$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:137950048$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Sgambato-Faure, Véronique</contributor><creatorcontrib>Plavén-Sigray, Pontus</creatorcontrib><creatorcontrib>Matheson, Granville James</creatorcontrib><creatorcontrib>Gustavsson, Petter</creatorcontrib><creatorcontrib>Stenkrona, Per</creatorcontrib><creatorcontrib>Halldin, Christer</creatorcontrib><creatorcontrib>Farde, Lars</creatorcontrib><creatorcontrib>Cervenka, Simon</creatorcontrib><title>Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Associations between dopamine receptor levels and pro- and antisocial behavior have previously been demonstrated in human subjects using positron emission tomography (PET) and self-rated measures of personality traits. So far, only one study has focused on the dopamine D1-receptor (D1-R), finding a positive correlation with the trait social desirability, which is characterized by low dominant and high affiliative behavior, while physical aggression showed a negative correlation. The aim of the present study was to replicate these previous findings using a new independent sample of subjects.
Twenty-six healthy males were examined with the radioligand [11C]SCH-23390, and completed the Swedish universities Scales of Personality (SSP) which includes measures of social desirability and physical trait aggression. The simplified reference tissue model with cerebellum as reference region was used to calculate BPND values in the whole striatum and limbic striatum. The two regions were selected since they showed strong association between D1-R availability and personality scores in the previous study. Pearson's correlation coefficients and replication Bayes factors were then employed to assess the replicability and robustness of previous results.
There were no significant correlations (all p values > 0.3) between regional BPND values and personality scale scores. Replication Bayes factors showed strong to moderate evidence in favor no relationship between D1-receptor availability and social desirability (striatum BF01 = 12.4; limbic striatum BF01 = 7.2) or physical aggression scale scores (limbic striatum BF01 = 3.3), compared to the original correlations.
We could not replicate the previous findings of associations between D1-R availability and either pro- or antisocial behavior as measured using the SSP. Rather, there was evidence in favor of failed replications of associations between BPND and scale scores. Potential reasons for these results are restrictive variance in both PET and personality outcomes due to high sample homogeneity, or that the previous findings were false positives.</description><subject>Adult</subject><subject>Aggression</subject><subject>Aggression - physiology</subject><subject>Aggressive behavior</subject><subject>Aggressiveness</subject><subject>Analysis</subject><subject>Antisocial personality disorder</subject><subject>Availability</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>Benzazepines</subject><subject>Biology and Life Sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Carbon Radioisotopes</subject><subject>Cerebellum</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Councils</subject><subject>Dopamine</subject><subject>Dopamine D1 receptors</subject><subject>Dopamine receptors</subject><subject>Emission analysis</subject><subject>Emission measurements</subject><subject>Emissions</subject><subject>Homogeneity</subject><subject>Human behavior</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medical screening</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine and Health Sciences</subject><subject>Neostriatum</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Personality</subject><subject>Personality - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plavén-Sigray, Pontus</au><au>Matheson, Granville James</au><au>Gustavsson, Petter</au><au>Stenkrona, Per</au><au>Halldin, Christer</au><au>Farde, Lars</au><au>Cervenka, Simon</au><au>Sgambato-Faure, Véronique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-03-15</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>e0193770</spage><epage>e0193770</epage><pages>e0193770-e0193770</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Associations between dopamine receptor levels and pro- and antisocial behavior have previously been demonstrated in human subjects using positron emission tomography (PET) and self-rated measures of personality traits. So far, only one study has focused on the dopamine D1-receptor (D1-R), finding a positive correlation with the trait social desirability, which is characterized by low dominant and high affiliative behavior, while physical aggression showed a negative correlation. The aim of the present study was to replicate these previous findings using a new independent sample of subjects.
Twenty-six healthy males were examined with the radioligand [11C]SCH-23390, and completed the Swedish universities Scales of Personality (SSP) which includes measures of social desirability and physical trait aggression. The simplified reference tissue model with cerebellum as reference region was used to calculate BPND values in the whole striatum and limbic striatum. The two regions were selected since they showed strong association between D1-R availability and personality scores in the previous study. Pearson's correlation coefficients and replication Bayes factors were then employed to assess the replicability and robustness of previous results.
There were no significant correlations (all p values > 0.3) between regional BPND values and personality scale scores. Replication Bayes factors showed strong to moderate evidence in favor no relationship between D1-receptor availability and social desirability (striatum BF01 = 12.4; limbic striatum BF01 = 7.2) or physical aggression scale scores (limbic striatum BF01 = 3.3), compared to the original correlations.
We could not replicate the previous findings of associations between D1-R availability and either pro- or antisocial behavior as measured using the SSP. Rather, there was evidence in favor of failed replications of associations between BPND and scale scores. Potential reasons for these results are restrictive variance in both PET and personality outcomes due to high sample homogeneity, or that the previous findings were false positives.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29543812</pmid><doi>10.1371/journal.pone.0193770</doi><tpages>e0193770</tpages><orcidid>https://orcid.org/0000-0001-5342-5641</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-03, Vol.13 (3), p.e0193770-e0193770 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2014442305 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aggression Aggression - physiology Aggressive behavior Aggressiveness Analysis Antisocial personality disorder Availability Bayes Theorem Bayesian analysis Benzazepines Biology and Life Sciences Brain - diagnostic imaging Brain - metabolism Brain Mapping Brain research Carbon Radioisotopes Cerebellum Correlation Correlation analysis Correlation coefficient Correlation coefficients Councils Dopamine Dopamine D1 receptors Dopamine receptors Emission analysis Emission measurements Emissions Homogeneity Human behavior Humans Magnetic Resonance Imaging Male Males Medical imaging Medical research Medical screening Medicin och hälsovetenskap Medicine and Health Sciences Neostriatum Neurosciences NMR Nuclear magnetic resonance Personality Personality - physiology Personality Tests Personality traits Physical Sciences Positron emission Positron emission tomography Psychiatry Psychology Radiopharmaceuticals Receptors, Dopamine D1 - metabolism Replication Research and Analysis Methods Social Behavior Social Sciences Studies Tomography |
| title | Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study |
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