Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS

The identification of easily measured, accurate diagnostic biomarkers for active tuberculosis (TB) will have a significant impact on global TB control efforts. Because of the host and pathogen complexities involved in TB pathogenesis, identifying a single biomarker that is adequately sensitive and s...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e103811-e103811
Hauptverfasser:	Kruh-Garcia, Nicole A, Wolfe, Lisa M, Chaisson, Lelia H, Worodria, William O, Nahid, Payam, Schorey, Jeff S, Davis, J Lucian, Dobos, Karen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Adhesins Adult Amino Acid Sequence Antigen 85B Antigens Apoptosis Bacterial Proteins - blood Biology and Life Sciences Biomarkers Biomarkers - blood Chronic illnesses Critical care Diagnostic systems Disease Ethics Exosomes Exosomes - metabolism Health aspects Hospitals Hostages Humans Immunology Infections Latent Tuberculosis - blood Latent Tuberculosis - diagnosis Macrophages Mass spectrometry Mass spectroscopy Medical diagnosis Medicine Medicine and Health Sciences Microscopy Molecular Sequence Data Mycobacterium tuberculosis Pathogenesis Pathogens Pathology Patients Peptide Fragments - blood Peptides Prospective Studies Proteins Proteome - metabolism Proteomics Spectroscopy Tuberculosis
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