Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum
Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum...
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| Veröffentlicht in: | PloS one 2018-03, Vol.13 (3), p.e0194284-e0194284 |
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| creator | Chen, Ciqiong Long, Li Zhang, Fusheng Chen, Qin Chen, Cheng Yu, Xiaorui Liu, Qingya Bao, Jinku Long, Zhangfu |
| description | Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase. |
| doi_str_mv | 10.1371/journal.pone.0194284 |
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In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0194284</identifier><identifier>PMID: 29543859</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Agricultural production ; Alcohols ; Antifungal activity ; Antifungal agents ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Biology and Life Sciences ; Biopesticides ; Botrytis cinerea ; Cell Membrane - drug effects ; Curcuma ; Curcuma - chemistry ; Curcuma longa ; Curcumin ; Education ; Energy metabolism ; Ergosterol ; Ergosterol - biosynthesis ; Fruits ; Fungal Proteins - metabolism ; Fungi ; Fungicides ; Fusarium ; Fusarium - drug effects ; Fusarium - metabolism ; Fusarium graminearum ; Fusarium oxysporum ; Glucose metabolism ; Health aspects ; Herbal medicine ; Laboratories ; Life sciences ; Medical research ; Medicine and Health Sciences ; Metabolism ; Multienzyme Complexes - metabolism ; NADH ; NADH oxidase ; NADH, NADPH Oxidoreductases - metabolism ; Nicotinamide adenine dinucleotide ; Oryza ; Penicillium ; Pesticides ; Physiological aspects ; Physiological effects ; Plant diseases ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Pleurotus ostreatus ; Proteins ; Proteome - drug effects ; Proteome - metabolism ; Proteomics ; Rhizopus oryzae ; Rice ; Sclerotinia sclerotiorum ; Succinate dehydrogenase ; Succinate Dehydrogenase - metabolism ; Synthesis ; tRNA ; Turmeric</subject><ispartof>PloS one, 2018-03, Vol.13 (3), p.e0194284-e0194284</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Chen et al 2018 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d219240adfc9aa4d7ee3f7caa456025d9e9efb869922670d0dc56fa03538eb773</citedby><cites>FETCH-LOGICAL-c692t-d219240adfc9aa4d7ee3f7caa456025d9e9efb869922670d0dc56fa03538eb773</cites><orcidid>0000-0003-1289-3400</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854386/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854386/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29543859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ciqiong</creatorcontrib><creatorcontrib>Long, Li</creatorcontrib><creatorcontrib>Zhang, Fusheng</creatorcontrib><creatorcontrib>Chen, Qin</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Yu, Xiaorui</creatorcontrib><creatorcontrib>Liu, Qingya</creatorcontrib><creatorcontrib>Bao, Jinku</creatorcontrib><creatorcontrib>Long, Zhangfu</creatorcontrib><title>Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase.</description><subject>Agricultural production</subject><subject>Alcohols</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biology and Life Sciences</subject><subject>Biopesticides</subject><subject>Botrytis cinerea</subject><subject>Cell Membrane - drug effects</subject><subject>Curcuma</subject><subject>Curcuma - chemistry</subject><subject>Curcuma longa</subject><subject>Curcumin</subject><subject>Education</subject><subject>Energy metabolism</subject><subject>Ergosterol</subject><subject>Ergosterol - biosynthesis</subject><subject>Fruits</subject><subject>Fungal Proteins - metabolism</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Fusarium</subject><subject>Fusarium - drug effects</subject><subject>Fusarium - metabolism</subject><subject>Fusarium graminearum</subject><subject>Fusarium oxysporum</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Laboratories</subject><subject>Life sciences</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Multienzyme Complexes - metabolism</subject><subject>NADH</subject><subject>NADH oxidase</subject><subject>NADH, NADPH Oxidoreductases - metabolism</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>Oryza</subject><subject>Penicillium</subject><subject>Pesticides</subject><subject>Physiological aspects</subject><subject>Physiological effects</subject><subject>Plant diseases</subject><subject>Plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Pleurotus ostreatus</subject><subject>Proteins</subject><subject>Proteome - drug effects</subject><subject>Proteome - metabolism</subject><subject>Proteomics</subject><subject>Rhizopus oryzae</subject><subject>Rice</subject><subject>Sclerotinia sclerotiorum</subject><subject>Succinate dehydrogenase</subject><subject>Succinate Dehydrogenase - metabolism</subject><subject>Synthesis</subject><subject>tRNA</subject><subject>Turmeric</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QDgig4Yz7adHIjDIOrAwsLft2GM0k6k6VNZpNmcf-9qdNdprIX0oukyfO-ac7bUxQvCZ4TVpOPVz4FB-18752ZYyJKuigfFadEMDrjFLPHR_OT4lmMVxhXbMH50-KEiqpki0qcFn7petskt4UWgertje1vP6AOrDu8GqR8Nxzh-ojAadQZtQNnY4d8g1YpqNQBan02QOZ3H7IIwTbLY4_OU4RgU4e2ATrrDITUPS-eNNBG82Icz4qf559_rL7OLi6_rFfLi5nigvYzTYmgJQbdKAFQ6toY1tQqTyuOaaWFEabZLLgQlPIaa6xVxRvALN_QbOqanRWvD7771kc51ipKiklZMkEwy8T6QGgPV3IfbAfhVnqw8u-CD1sJobeqNZKXUBG6oayqs1wzUZZcEMFBGKAbPXh9Gk9Lm85olasVoJ2YTnec3cmtv5HVYgiCZ4N3o0Hw18nEXnY2KtO24IxPh-8WFeGMZPTNP-jDtxupHKyR1jV-yGYwlcuKEUJrSmmm5g9Q-dGmsyqn3ti8PhG8nwgy0-fYt5BilOvv3_6fvfw1Zd8esTsDbb-Lvk299S5OwfIAquBjDKa5LzLBcuiLu2rI4aeVY19k2avjgO5Fd43A_gDeTgiN</recordid><startdate>20180315</startdate><enddate>20180315</enddate><creator>Chen, Ciqiong</creator><creator>Long, Li</creator><creator>Zhang, Fusheng</creator><creator>Chen, Qin</creator><creator>Chen, Cheng</creator><creator>Yu, Xiaorui</creator><creator>Liu, Qingya</creator><creator>Bao, Jinku</creator><creator>Long, Zhangfu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1289-3400</orcidid></search><sort><creationdate>20180315</creationdate><title>Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum</title><author>Chen, Ciqiong ; Long, Li ; Zhang, Fusheng ; Chen, Qin ; Chen, Cheng ; Yu, Xiaorui ; Liu, Qingya ; Bao, Jinku ; Long, Zhangfu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d219240adfc9aa4d7ee3f7caa456025d9e9efb869922670d0dc56fa03538eb773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Agricultural production</topic><topic>Alcohols</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ciqiong</au><au>Long, Li</au><au>Zhang, Fusheng</au><au>Chen, Qin</au><au>Chen, Cheng</au><au>Yu, Xiaorui</au><au>Liu, Qingya</au><au>Bao, Jinku</au><au>Long, Zhangfu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-03-15</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>e0194284</spage><epage>e0194284</epage><pages>e0194284-e0194284</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29543859</pmid><doi>10.1371/journal.pone.0194284</doi><tpages>e0194284</tpages><orcidid>https://orcid.org/0000-0003-1289-3400</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-03, Vol.13 (3), p.e0194284-e0194284 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2014439103 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Agricultural production Alcohols Antifungal activity Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Biology and Life Sciences Biopesticides Botrytis cinerea Cell Membrane - drug effects Curcuma Curcuma - chemistry Curcuma longa Curcumin Education Energy metabolism Ergosterol Ergosterol - biosynthesis Fruits Fungal Proteins - metabolism Fungi Fungicides Fusarium Fusarium - drug effects Fusarium - metabolism Fusarium graminearum Fusarium oxysporum Glucose metabolism Health aspects Herbal medicine Laboratories Life sciences Medical research Medicine and Health Sciences Metabolism Multienzyme Complexes - metabolism NADH NADH oxidase NADH, NADPH Oxidoreductases - metabolism Nicotinamide adenine dinucleotide Oryza Penicillium Pesticides Physiological aspects Physiological effects Plant diseases Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Pleurotus ostreatus Proteins Proteome - drug effects Proteome - metabolism Proteomics Rhizopus oryzae Rice Sclerotinia sclerotiorum Succinate dehydrogenase Succinate Dehydrogenase - metabolism Synthesis tRNA Turmeric |
| title | Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum |
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