Inhibition of histone H3K9 acetylation by anacardic acid can correct the over-expression of Gata4 in the hearts of fetal mice exposed to alcohol during pregnancy

Cardiovascular malformations can be caused by abnormalities in Gata4 expression during fetal development. In a previous study, we demonstrated that ethanol exposure could lead to histone hyperacetylation and Gata4 over-expression in fetal mouse hearts. However, the potential mechanisms of histone hy...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104135
Hauptverfasser:	Peng, Chang, Zhu, Jing, Sun, Hui-Chao, Huang, Xu-Pei, Zhao, Wei-An, Zheng, Min, Liu, Ling-Juan, Tian, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acetates Acetylation Acetylation - drug effects Acids Alcohol Alcohols Anacardic Acids - pharmacology Analysis Animals Base Sequence Binding Biology and Life Sciences Cardiomyocytes Cardiovascular disease Child development Children & youth Chromatin Congenital diseases Cooperation Deoxyribonucleic acid DNA DNA methylation Epigenetics Ethanol Ethanol - toxicity Event-related potentials Exposure Female Fetal development Fetal Development - drug effects GATA4 Transcription Factor - chemistry GATA4 Transcription Factor - metabolism Gene expression Gene Expression Regulation, Developmental Genes Heart Heart - embryology Heart diseases Histone deacetylase Histones - metabolism Homogenization Hospitals Laboratories Major histocompatibility complex Medical research Medicine and Health Sciences Mice Mice, Inbred Strains Molecular Sequence Data Overexpression Pediatrics Pregnancy Pregnant women Prenatal Exposure Delayed Effects Promoter Regions, Genetic Proteins RNA RNA polymerase Sequence Analysis, DNA Stem cells Transcription factors
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