Postnatal hyperoxia exposure differentially affects hepatocytes and liver haemopoietic cells in newborn rats

Premature newborns are frequently exposed to hyperoxic conditions and experimental data indicate modulation of liver metabolism by hyperoxia in the first postnatal period. Conversely, nothing is known about possible modulation of growth factors and signaling molecules involved in other hyperoxic res...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e105005-e105005
Hauptverfasser:	Marconi, Guya Diletta, Zara, Susi, De Colli, Marianna, Di Valerio, Valentina, Rapino, Monica, Zaramella, Patrizia, Dedja, Arben, Macchi, Veronica, De Caro, Raffaele, Porzionato, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Animals, Newborn Apoptosis Biology and Life Sciences Design factors Disease Models, Animal Experimental design Exposure Female Gelatinase B Growth factors Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Hemopoiesis Hepatocytes Hepatocytes - metabolism Hepatocytes - pathology Humans Hyperoxia Hyperoxia - metabolism Hyperoxia - pathology Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Infant, Newborn Intensive care Laboratory animals Leukemia Liver Liver - metabolism Liver - pathology Male Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Medicine Medicine and Health Sciences Metabolism Metalloproteinase Modulation Neonates Newborn babies NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Oxidative stress Pharmacy Physiological aspects Rats Rats, Sprague-Dawley Research and Analysis Methods Rodents Signaling Stem cells Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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