Activation of nuclear factor kappa B in the hepatic stellate cells of mice with schistosomiasis japonica

Schistosomiasis japonica is a serious tropical parasitic disease in humans, which causes inflammation and fibrosis of the liver. Hepatic stellate cells (HSCs) are known to play an important role in schistosome-induced fibrosis, but their role in schistosome-induced inflammation is still largely unkn...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104323-e104323
Hauptverfasser:	He, Xing, Pu, Guangbin, Tang, Rui, Zhang, Dongmei, Pan, Weiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal models Animals Apoptosis Biology and Life Sciences CCL3 protein Chemokines Chemotherapy Disease Models, Animal Disease Progression Eggs Fibrosis Gastroenterology Gene expression Hepatic Stellate Cells - metabolism Hepatocytes Immunohistochemistry Infections Infectious diseases Inflammation Laboratory animals Liver Liver - metabolism Liver - parasitology Liver - pathology Male Medical research Medicine and Health Sciences Mice MicroRNAs MicroRNAs - genetics Monocyte chemoattractant protein 1 NF-kappa B - metabolism NF-κB protein Parasitic diseases Pathogenesis Rodents Schistosoma japonicum Schistosomiasis Schistosomiasis japonica - metabolism Schistosomiasis japonica - pathology Signal Transduction Signaling Stellate cells TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Viral infections
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