Cognitive impairment in myotonic dystrophy type 1 is associated with white matter damage

To investigate grey (GM) and white matter (WM) abnormalities and their effects on cognitive and behavioral deficits in a large, phenotypically and genotypically well-characterized cohort of classic adult (aDM1, age at onset ≥ 20 years) or juvenile (jDM1, age at onset

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Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104697-e104697
Hauptverfasser:	Caso, Francesca, Agosta, Federica, Peric, Stojan, Rakočević-Stojanović, Vidosava, Copetti, Massimiliano, Kostic, Vladimir S, Filippi, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adolescent Adult Age Age of Onset Aging Atrophy Biology and Life Sciences Brain Brain damage Brain injury Brain research Case-Control Studies Cerebral hemispheres Child Child, Preschool Cognition Disorders - diagnosis Cognition Disorders - etiology Cognitive ability Congenital diseases Control methods Damage assessment Deoxyribonucleic acid Developmental stages Disease DNA Dystrophy Fatigue Female Gray Matter - pathology Health care facilities Humans Impairment Kinases Magnetic Resonance Imaging Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Myotonic dystrophy Myotonic Dystrophy - complications Myotonic Dystrophy - diagnosis Myotonic Dystrophy - pathology Neurology Neuropsychological Tests Neurosciences Patients Personality Pyramidal tracts Regional analysis Sensorimotor system Sleep disorders Structural damage Substantia alba Substrates White Matter - pathology Young Adult
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Beschreibung
Zusammenfassung:	To investigate grey (GM) and white matter (WM) abnormalities and their effects on cognitive and behavioral deficits in a large, phenotypically and genotypically well-characterized cohort of classic adult (aDM1, age at onset ≥ 20 years) or juvenile (jDM1, age at onset
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0104697