Small-size circulating endothelial microparticles in coronary artery disease
Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter
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| Veröffentlicht in: | PloS one 2014-08, Vol.9 (8), p.e104528-e104528 |
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| creator | Hu, Shuai-Shuai Zhang, Hong-Gang Zhang, Qiu-Ju Xiu, Rui-Juan |
| description | Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter |
| doi_str_mv | 10.1371/journal.pone.0104528 |
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| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_2013829349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_ba1504ea802842d394904b91f7674abd</doaj_id><sourcerecordid>2013829349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c592t-a274ca1a76a7ab01ca02073f9f0724059417aea0490215467e93a00264fde7293</originalsourceid><addsrcrecordid>eNptUk1v1DAQjRCIlsI_QBCJC5cs4684viChio9KK3EAztbEmWy9cuLFTirBryfLplWLOI018-bNvPEripcMNkxo9m4f5zRi2BziSBtgIBVvHhXnzAhe1RzE43vvs-JZznsAJZq6flqcccVY3dT6vNh-GzCEKvvfVDqf3Bxw8uOupLGL0zUFj6EcvEvxgGnyLlAu_Vi6mOKI6Ve5JGkJnc-EmZ4XT3oMmV6s8aL48enj98sv1fbr56vLD9vKKcOnCrmWDhnqGjW2wBwCBy1604PmEpSRTCMhSAOcKVlrMgIBeC37jjQ34qJ4feI9hJjteohsOTDRLGV5RFydEF3EvT0kPyzb2oje_k3EtLOrHtsiUyAJG-CN5J0wy1jZGtbrWktsu4Xr_TptbgfqHI1TwvCA9GFl9Nd2F2-sZAJUoxeCtytBij9nypMdfHYUAo4U52yZUkKDNuoIffMP9P_q5Am1_EvOifq7ZRjYozluu-zRHHY1x9L26r6Qu6ZbN4g_D023cA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2013829349</pqid></control><display><type>article</type><title>Small-size circulating endothelial microparticles in coronary artery disease</title><source>MEDLINE</source><source>Directory of Open Access Journals</source><source>Public Library of Science</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Hu, Shuai-Shuai ; Zhang, Hong-Gang ; Zhang, Qiu-Ju ; Xiu, Rui-Juan</creator><contributor>Aikawa, Masanori</contributor><creatorcontrib>Hu, Shuai-Shuai ; Zhang, Hong-Gang ; Zhang, Qiu-Ju ; Xiu, Rui-Juan ; Aikawa, Masanori</creatorcontrib><description>Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter <0.5 µm) are lacking. The aim of this study was to detect small-size endothelial microparticles (SEMPs) in CAD patients to monitor endothelial dysfunction.
In total, 19 CAD patients and 14 healthy subjects were recruited. The absolute numbers and percentages of CD31(+)/CD42b- SEMPs and CD62E(+) SEMPs were determined by flow cytometry. Clinical parameters were also recorded.
The mean percentage of CD62E(+) SEMPs was higher in the CAD patient group than in the healthy subject group. The area under the receiver operating characteristic curve of the percentage of CD62E(+) SEMPs was 0.795, and the cut-off value was 1.35. There was no correlation between the percentage of CD62E(+) SEMPs and various clinical parameters.
The percentage of CD62E(+) SEMPs is a potential biomarker for monitoring endothelial function in CAD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0104528</identifier><identifier>PMID: 25116867</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Bioindicators ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Blood platelets ; Cardiovascular disease ; Case-Control Studies ; Cell-Derived Microparticles - chemistry ; Cell-Derived Microparticles - metabolism ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - metabolism ; Coronary vessels ; Cytometry ; Diabetes ; E-Selectin - metabolism ; Endothelial Cells - metabolism ; Endothelium, Vascular - metabolism ; Experiments ; Family planning ; Female ; Flow Cytometry ; Heart diseases ; Heart failure ; Humans ; Hypertension ; Laboratories ; Lipids - blood ; Male ; Medical research ; Medicine and Health Sciences ; Microparticles ; Microscopy ; Middle Aged ; Parameters ; Patients ; Plasma ; Risk Factors ; ROC Curve ; Studies ; Values</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e104528-e104528</ispartof><rights>2014 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Hu et al 2014 Hu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-a274ca1a76a7ab01ca02073f9f0724059417aea0490215467e93a00264fde7293</citedby><cites>FETCH-LOGICAL-c592t-a274ca1a76a7ab01ca02073f9f0724059417aea0490215467e93a00264fde7293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130587/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130587/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25116867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aikawa, Masanori</contributor><creatorcontrib>Hu, Shuai-Shuai</creatorcontrib><creatorcontrib>Zhang, Hong-Gang</creatorcontrib><creatorcontrib>Zhang, Qiu-Ju</creatorcontrib><creatorcontrib>Xiu, Rui-Juan</creatorcontrib><title>Small-size circulating endothelial microparticles in coronary artery disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter <0.5 µm) are lacking. The aim of this study was to detect small-size endothelial microparticles (SEMPs) in CAD patients to monitor endothelial dysfunction.
In total, 19 CAD patients and 14 healthy subjects were recruited. The absolute numbers and percentages of CD31(+)/CD42b- SEMPs and CD62E(+) SEMPs were determined by flow cytometry. Clinical parameters were also recorded.
The mean percentage of CD62E(+) SEMPs was higher in the CAD patient group than in the healthy subject group. The area under the receiver operating characteristic curve of the percentage of CD62E(+) SEMPs was 0.795, and the cut-off value was 1.35. There was no correlation between the percentage of CD62E(+) SEMPs and various clinical parameters.
The percentage of CD62E(+) SEMPs is a potential biomarker for monitoring endothelial function in CAD.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Bioindicators</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Blood platelets</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Cell-Derived Microparticles - chemistry</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary vessels</subject><subject>Cytometry</subject><subject>Diabetes</subject><subject>E-Selectin - metabolism</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Experiments</subject><subject>Family planning</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Laboratories</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Microparticles</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>Parameters</subject><subject>Patients</subject><subject>Plasma</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Studies</subject><subject>Values</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIlsI_QBCJC5cs4684viChio9KK3EAztbEmWy9cuLFTirBryfLplWLOI018-bNvPEripcMNkxo9m4f5zRi2BziSBtgIBVvHhXnzAhe1RzE43vvs-JZznsAJZq6flqcccVY3dT6vNh-GzCEKvvfVDqf3Bxw8uOupLGL0zUFj6EcvEvxgGnyLlAu_Vi6mOKI6Ve5JGkJnc-EmZ4XT3oMmV6s8aL48enj98sv1fbr56vLD9vKKcOnCrmWDhnqGjW2wBwCBy1604PmEpSRTCMhSAOcKVlrMgIBeC37jjQ34qJ4feI9hJjteohsOTDRLGV5RFydEF3EvT0kPyzb2oje_k3EtLOrHtsiUyAJG-CN5J0wy1jZGtbrWktsu4Xr_TptbgfqHI1TwvCA9GFl9Nd2F2-sZAJUoxeCtytBij9nypMdfHYUAo4U52yZUkKDNuoIffMP9P_q5Am1_EvOifq7ZRjYozluu-zRHHY1x9L26r6Qu6ZbN4g_D023cA</recordid><startdate>20140812</startdate><enddate>20140812</enddate><creator>Hu, Shuai-Shuai</creator><creator>Zhang, Hong-Gang</creator><creator>Zhang, Qiu-Ju</creator><creator>Xiu, Rui-Juan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140812</creationdate><title>Small-size circulating endothelial microparticles in coronary artery disease</title><author>Hu, Shuai-Shuai ; Zhang, Hong-Gang ; Zhang, Qiu-Ju ; Xiu, Rui-Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-a274ca1a76a7ab01ca02073f9f0724059417aea0490215467e93a00264fde7293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Bioindicators</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Blood platelets</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Cell-Derived Microparticles - chemistry</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary vessels</topic><topic>Cytometry</topic><topic>Diabetes</topic><topic>E-Selectin - metabolism</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Experiments</topic><topic>Family planning</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Laboratories</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Microparticles</topic><topic>Microscopy</topic><topic>Middle Aged</topic><topic>Parameters</topic><topic>Patients</topic><topic>Plasma</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Studies</topic><topic>Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Shuai-Shuai</creatorcontrib><creatorcontrib>Zhang, Hong-Gang</creatorcontrib><creatorcontrib>Zhang, Qiu-Ju</creatorcontrib><creatorcontrib>Xiu, Rui-Juan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Shuai-Shuai</au><au>Zhang, Hong-Gang</au><au>Zhang, Qiu-Ju</au><au>Xiu, Rui-Juan</au><au>Aikawa, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-size circulating endothelial microparticles in coronary artery disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-08-12</date><risdate>2014</risdate><volume>9</volume><issue>8</issue><spage>e104528</spage><epage>e104528</epage><pages>e104528-e104528</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter <0.5 µm) are lacking. The aim of this study was to detect small-size endothelial microparticles (SEMPs) in CAD patients to monitor endothelial dysfunction.
In total, 19 CAD patients and 14 healthy subjects were recruited. The absolute numbers and percentages of CD31(+)/CD42b- SEMPs and CD62E(+) SEMPs were determined by flow cytometry. Clinical parameters were also recorded.
The mean percentage of CD62E(+) SEMPs was higher in the CAD patient group than in the healthy subject group. The area under the receiver operating characteristic curve of the percentage of CD62E(+) SEMPs was 0.795, and the cut-off value was 1.35. There was no correlation between the percentage of CD62E(+) SEMPs and various clinical parameters.
The percentage of CD62E(+) SEMPs is a potential biomarker for monitoring endothelial function in CAD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25116867</pmid><doi>10.1371/journal.pone.0104528</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Apoptosis Bioindicators Biology and Life Sciences Biomarkers Biomarkers - blood Biomarkers - metabolism Blood platelets Cardiovascular disease Case-Control Studies Cell-Derived Microparticles - chemistry Cell-Derived Microparticles - metabolism Coronary artery Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - metabolism Coronary vessels Cytometry Diabetes E-Selectin - metabolism Endothelial Cells - metabolism Endothelium, Vascular - metabolism Experiments Family planning Female Flow Cytometry Heart diseases Heart failure Humans Hypertension Laboratories Lipids - blood Male Medical research Medicine and Health Sciences Microparticles Microscopy Middle Aged Parameters Patients Plasma Risk Factors ROC Curve Studies Values |
| title | Small-size circulating endothelial microparticles in coronary artery disease |
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