Dietary squalene increases high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice

Squalene, the main hydrocarbon in the unsaponifiable fraction of virgin olive oil, is involved in cholesterol synthesis and it has been reported to own antiatherosclerotic and antiesteatosic effects. However, the squalene's role on lipid plasma parameters and the influence of genotype on this e...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104224
Hauptverfasser:	Gabás-Rivera, Clara, Barranquero, Cristina, Martínez-Beamonte, Roberto, Navarro, María A, Surra, Joaquín C, Osada, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apolipoprotein E Apolipoproteins Aryldialkylphosphatase - blood Atherosclerosis Biology and Life Sciences Blood Glucose - drug effects Body Weight - drug effects Cholesterol Cholesterol, HDL - blood Diabetes Diet Dietary Supplements Esterification Gene expression Gene Expression Regulation - drug effects Genetic engineering Genotypes High density lipoprotein Lecithin Lipids Lipids - blood Lipoproteins Lipoproteins - blood Lipoproteins - metabolism Liver - anatomy & histology Liver - drug effects Liver - metabolism Low density lipoprotein Male Malondialdehyde Medicine and Health Sciences Mice Mice, Knockout Oils & fats Olive oil Organ Size - drug effects Oxidative stress Oxidative Stress - drug effects Oxygen Parameters Paraoxonase Paraoxonase 1 Phenotypes Phosphatidylcholine Proteomics Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Squalene Squalene - administration & dosage
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