Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort

Adverse maternal environments can lead to increased fetal exposure to maternal cortisol, which can cause infant neurobehavioral deficits. The placenta regulates fetal cortisol exposure and response, and placental DNA methylation can influence this function. FK506 binding protein (FKBP5) is a negativ...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104913
Hauptverfasser:	Paquette, Alison G, Lester, Barry M, Koestler, Devin C, Lesseur, Corina, Armstrong, David A, Marsit, Carmen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Analysis Arousal Arousal - genetics Biology and life sciences Bisulfite Brain Cohort Studies Cortisol Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Epigenetic inheritance Epigenetics Exposure Female Fetuses Gene expression Genetic aspects Genetic diversity Genetic research Genetic Variation Genotype Genotypes Glucocorticoids Humans Hydrocortisone - physiology Infant Behavior - physiology Infant, Newborn Infants Male Maternal-Fetal Exchange - genetics Maternal-Fetal Exchange - physiology Medicine and Health Sciences Mental disorders Methylation Neonates Newborn babies Placenta Placenta - metabolism Post traumatic stress disorder Posttraumatic stress disorder Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - psychology Protein binding Psychiatric-mental health nursing Risk Risk groups RNA RNA, Messenger - genetics RNA, Messenger - metabolism Single-nucleotide polymorphism Tacrolimus Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Tacrolimus-binding protein Young Adult
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