Mesenchymal stromal cell proliferation, gene expression and protein production in human platelet-rich plasma-supplemented media

Platelet-rich plasma (PRP) is increasingly used as a cell culture supplement, in order to reduce the contact of human cells with animal-derived products during in vitro expansion. The effect of supplementation changes on cell growth and protein production is not fully characterized. Human mesenchyma...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104662
Hauptverfasser:	Amable, Paola Romina, Teixeira, Marcus Vinicius Telles, Carias, Rosana Bizon Vieira, Granjeiro, José Mauro, Borojevic, Radovan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis - drug effects Adipogenesis - genetics Adipose tissue Angiogenesis Antigens, Surface - metabolism Biology and Life Sciences Biomarkers - metabolism Biomedical materials Blood platelets Bone marrow Calcium Cell culture Cell differentiation Cell Differentiation - drug effects Cell Differentiation - genetics Cell Proliferation Cell surface Chemokines Clinical trials Culture media Culture Media - pharmacology Differentiation (biology) Dose-Response Relationship, Drug Extracellular matrix Gene Expression Gene Expression Profiling Growth factors Humans Inflammation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme Osteogenesis - drug effects Osteogenesis - genetics Platelet-Rich Plasma Platelets Protein Biosynthesis Proteins Stem cells Stromal cells Supplements Surface markers Tissues
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