TLR4-mediated expression of Mac-1 in monocytes plays a pivotal role in monocyte adhesion to vascular endothelium

Toll-like receptor 4 (TLR4) is known to mediate monocyte adhesion to endothelial cells, however, its role on the expression of monocyte adhesion molecules is unclear. In the present study, we investigated the role of TLR4 on the expression of monocyte adhesion molecules, and determined the functiona...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104588-e104588
Hauptverfasser:	Lee, Seung Jin, Choi, Eun Kyoung, Seo, Kyo Won, Bae, Jin Ung, Park, So Youn, Kim, Chi Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Aorta Aorta - metabolism Arachidonate 5-lipoxygenase Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Arteriosclerosis Atherosclerosis Attenuation Biology and Life Sciences Cell Adhesion Cell adhesion molecules Cell Line Endothelial cells Endothelium Endothelium, Vascular - metabolism Foam Foams Gene expression Gene Expression Regulation Human Umbilical Vein Endothelial Cells - metabolism Humans Immune system In vivo methods and tests Inflammation Laboratory animals Lipid A Lipids Lipoxygenase Mac1 protein Macrophage-1 Antigen - genetics Macrophage-1 Antigen - metabolism Medicine Mice Mice, Knockout Monocytes Monocytes - metabolism mRNA Neutrophils Pathogenesis Pharmacology Proteins Tissue engineering TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors
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