Gender effect in experimental models of human medulloblastoma: does the estrogen receptor β signaling play a role?

The male-to-female sex ratio for medulloblastoma (MB) is approximately 1.5∶1, female gender being also a favorable prognostic factor. This study aimed at evaluating the impact of gender on MB tumorigenesis. In vitro activity of 17β-estradiol (E2), DPN [2,3-bis(4-hydroxyphenyl)-propionitrile, a selec...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101623
Hauptverfasser:	Ciucci, Alessandra, Meco, Daniela, De Stefano, Ilaria, Travaglia, Daniele, Zannoni, Gian Franco, Scambia, Giovanni, Riccardi, Riccardo, Saran, Anna, Mancuso, Mariateresa, Gallo, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Androgen receptors Animal models Animals Apoptosis - drug effects Biomarkers, Tumor - metabolism Biotechnology Brain cancer Carcinogenesis - drug effects Carcinogenesis - metabolism Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cerebellar Neoplasms - metabolism Cerebellar Neoplasms - pathology Cerebellar Neoplasms - physiopathology Cyclin-dependent kinase Cyclin-dependent kinase inhibitor p21 Differentiation Dihydrotestosterone Dihydrotestosterone - pharmacology Enzyme inhibitors Estradiol - pharmacology Estrogen Receptor beta - agonists Estrogen Receptor beta - metabolism Estrogens Female Females Gender Glial fibrillary acidic protein Hormones Humans In vitro methods and tests Insulin Insulin-like growth factor I Male Males Medicine and Health Sciences Medulloblastoma Medulloblastoma - metabolism Medulloblastoma - pathology Medulloblastoma - physiopathology Mice Nestin Neuronal-glial interactions Nitriles - pharmacology p53 Protein Phenols - pharmacology Phosphopyruvate hydratase Propionitrile Pyrazole Pyrazoles - pharmacology Sex Characteristics Sex hormones Sex ratio Signal Transduction - drug effects Signaling Tumorigenesis Tumors
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