Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo

The liver plays a vital role in metabolism, detoxification, digestion, and the maintenance of homeostasis. During development, the vertebrate embryonic liver undergoes a series of morphogenic processes known as hepatogenesis. Hepatogenesis can be separated into three interrelated processes: endoderm...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101980
Hauptverfasser:	Lin, Tzung-Yi, Chou, Chi-Fu, Chung, Hsin-Yu, Chiang, Chia-Yin, Li, Chung-Hao, Wu, Jen-Leih, Lin, Han-Jia, Pai, Tun-Wen, Hu, Chin-Hwa, Tzou, Wen-Shyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - deficiency Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Binding sites Biology and Life Sciences Biotechnology Cell adhesion Cell migration Cell proliferation Cell Proliferation - drug effects Cholesterol Cobalt - pharmacology Danio rerio Detoxification Differentiation Embryo Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Embryogenesis Embryonic development Embryonic growth stage Embryos Endoderm Fibroblast Growth Factors - metabolism Gene expression Gene Expression Regulation, Developmental - drug effects Gene Knockdown Techniques Gene regulation Hepatocyte Growth Factor - metabolism Homeostasis Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factors Intestines - embryology Liver Liver - cytology Liver - embryology Localization Metabolism Organ Size - drug effects Pancreas, Exocrine - embryology Phenotype Phenotypes Physiological aspects Promoter Regions, Genetic - genetics Proteins Regulatory sequences Research and Analysis Methods Response Elements - genetics RNA Rodents Sequences Signaling Specifications Terrestrial environments Transcription (Genetics) Transcription factors Transcription, Genetic Wnt Signaling Pathway - drug effects Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics
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