Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice

Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colitis chronicit...

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Veröffentlicht in:	PloS one 2014, Vol.9 (5), p.e97532
Hauptverfasser:	Rodrigues-Sousa, Tiago, Ladeirinha, Ana Filipa, Santiago, Ana Raquel, Carvalheiro, Helena, Raposo, Bruno, Alarcão, Ana, Cabrita, António, Holmdahl, Rikard, Carvalho, Lina, Souto-Carneiro, M Margarida
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity Biology and Life Sciences CD4 antigen Chronic Disease Chronic granulomatous disease Colitis Colitis - chemically induced Colitis - genetics Colitis - metabolism Colitis - pathology Colon Cytokines Cytokines - biosynthesis Cytokines - blood Deregulation Dextran Dextran sulfate Dextran Sulfate - adverse effects Disease Models, Animal Histopathology Immunodeficiency Immunohistochemistry Infiltration Inflammation Inflammation Mediators - blood Inflammation Mediators - metabolism Inflammatory bowel disease Interleukin 10 Interleukin 6 Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Leucine Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Leukocytes Leukocytes (neutrophilic) Leukocytes - immunology Leukocytes - metabolism Leukocytes - pathology LRRK2 protein Lymphocytes Lymphocytes B Macrophages Male Medicin och hälsovetenskap Mice Mice, Knockout Monocytes Mucosa Mutants Mutation NAD(P)H oxidase NADPH Oxidases - genetics Oxygen Phenotype Phosphorylation Primary immunodeficiencies Protein-Serine-Threonine Kinases - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Sodium γ-Interferon
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