Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases

Cognitive impairments of different aetiology share alterations in iron and lipid homeostasis with mutual relationships. Since iron and cholesterol accumulation impact on neurodegenerative disease, the associated gene variants are appealing candidate targets for risk and disease progression assessmen...

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Veröffentlicht in:	PloS one 2018-03, Vol.13 (3), p.e0193867-e0193867
Hauptverfasser:	Tisato, Veronica, Zuliani, Giovanni, Vigliano, Marco, Longo, Giovanna, Franchini, Eugenia, Secchiero, Paola, Zauli, Giorgio, Paraboschi, Elvezia Maria, Vikram Singh, Ajay, Serino, Maria Luisa, Ortolani, Beatrice, Zurlo, Amedeo, Bosi, Cristina, Greco, Antonio, Seripa, Davide, Asselta, Rosanna, Gemmati, Donato
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer's disease Alzheimers disease Analysis Apolipoprotein E Apolipoprotein E4 Apolipoproteins Apolipoproteins E - genetics Apoptosis Biochemistry Biology and Life Sciences Brain Brain research Cation Transport Proteins - genetics Cholesterol Coding Coexistence Cognitive ability Cognitive disorders Cognitive Dysfunction - genetics Dementia disorders Dementia, Vascular - genetics Female Gene Expression Regulation - genetics Genes Genetic aspects Genetic Predisposition to Disease Genetics Geriatrics Health risks Hemochromatosis Hemochromatosis Protein - genetics Hepcidin Hepcidins - genetics HFE protein Homeostasis Homeostasis - genetics Homozygotes Humans Impairment Iron Iron - metabolism Laboratories Lipid metabolism Lipids Male Medicine Medicine and Health Sciences Mental Status and Dementia Tests Metabolism Molecular biology Morphology Multiple sclerosis Mutation Neurodegeneration Oxidative stress Patients Pharmacogenetics Pharmacology Physical Sciences Polymorphism, Single Nucleotide Protein-protein interactions Proteins Reduction Risk analysis Risk Factors Risk reduction Single nucleotide polymorphisms Single-nucleotide polymorphism Surgery Target recognition Therapeutic applications Thrombosis Transferrin Transferrin - genetics Transferrins Transporter Vascular dementia
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