Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice

The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactive constituent of cannabis, Δ(9)-tetrahydrocannabin...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e34129
Hauptverfasser:	Long, Leonora E, Chesworth, Rose, Huang, Xu-Feng, Wong, Alexander, Spiro, Adena, McGregor, Iain S, Arnold, Jonathon C, Karl, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotics Anxiety Anxiety - chemically induced Autoradiography Behavior, Animal - drug effects Behavior, Animal - physiology Binding Biology Blood Brain research Cannabidiol - blood Cannabidiol - pharmacology Cannabinoids Cannabis Cell Membrane - metabolism Chromatography Constituents Drug dosages Exploratory Behavior - drug effects Female Genotype & phenotype Genotypes Hyperactivity Locomotion - drug effects Male Marijuana Mass spectrometry Medicine Mental disorders Mice Mutation Neuregulin Neuregulin 1 Neuregulin-1 - chemistry Neuregulin-1 - genetics Neuregulin-1 - metabolism Neurosciences Pharmacokinetics Pharmacology Plasma Protein Structure, Tertiary Psychopharmacology Psychotropic drugs Receptor density Receptor, Serotonin, 5-HT2A - metabolism Rodents Schizophrenia Scientific imaging Sensory Gating - drug effects Serotonin S2 receptors Social aspects Social behavior Studies Substantia nigra Tetrahydrocannabinol Time Factors Tranquilizing drugs Transmembrane domains Withdrawal γ-Aminobutyric acid A receptors
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