Effects of human interleukins in the transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24 designed to assess the transcriptional activity of vitamin D receptor

The role of vitamin D receptor (VDR) in immune responses has been broadly studied and it has been shown that activated VDR alters the levels of some interleukins (ILs). In this study, we studied the opposite, i.e. whether 13 selected pro-inflammatory and anti-inflammatory ILs influence the transcrip...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0193655-e0193655
Hauptverfasser:	Bartonkova, Iveta, Kallay, Enikoe, Dvorak, Zdenek
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics Androgens Biology and Life Sciences Biotechnology Calcitriol Cell Line Cell lines Crosstalk Cytokines Gene expression Genes, Reporter - genetics Genetic aspects Genetic engineering Genetic research Health aspects Humans Immune response Inflammation Interleukin 13 Interleukin 4 Interleukins Interleukins - pharmacology Ligands Medicine and Health Sciences Metabolism Physical sciences Prostate cancer Receptors, Calcitriol - genetics Research and Analysis Methods Signal transduction Signaling Transcription Transcription (Genetics) Transcription factors Transcription, Genetic - drug effects Transfection Transgenes - genetics Transgenic Tumor necrosis factor-TNF Vitamin D Vitamin D receptors Vitamin D-24-hydroxylase Vitamin D3 24-Hydroxylase - genetics
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