Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia
The mechanism of general anesthesia (GA) has been explored for hundreds of years, but unclear. Previous studies indicated a possible correlation between NREM sleep and GA. The purpose of this study is to compare them by in vivo human brain function to probe the neuromechanism of consciousness, so as...
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| description | The mechanism of general anesthesia (GA) has been explored for hundreds of years, but unclear. Previous studies indicated a possible correlation between NREM sleep and GA. The purpose of this study is to compare them by in vivo human brain function to probe the neuromechanism of consciousness, so as to find out a clue to GA mechanism.
24 healthy participants were equally assigned to sleep or propofol sedation group by sleeping ability. EEG and Ramsay Sedation Scale were applied to determine sleep stage and sedation depth respectively. Resting-state functional magnetic resonance imaging (RS-fMRI) was acquired at each status. Regional homogeneity (ReHo) and seed-based whole brain functional connectivity maps (WB-FC maps) were compared.
During sleep, ReHo primarily weakened on frontal lobe (especially preoptic area), but strengthened on brainstem. While during sedation, ReHo changed in various brain areas, including cingulate, precuneus, thalamus and cerebellum. Cingulate, fusiform and insula were concomitance of sleep and sedation. Comparing to sleep, FCs between the cortex and subcortical centers (centralized in cerebellum) were significantly attenuated under sedation. As sedation deepening, cerebellum-based FC maps were diminished, while thalamus- and brainstem-based FC maps were increased.
There're huge distinctions in human brain function between sleep and GA. Sleep mainly rely on brainstem and frontal lobe function, while sedation is prone to affect widespread functional network. The most significant differences exist in the precuneus and cingulate, which may play important roles in mechanisms of inducing unconciousness by anesthetics.
Institutional Review Board (IRB) ChiCTR-IOC-15007454. |
| doi_str_mv | 10.1371/journal.pone.0192358 |
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24 healthy participants were equally assigned to sleep or propofol sedation group by sleeping ability. EEG and Ramsay Sedation Scale were applied to determine sleep stage and sedation depth respectively. Resting-state functional magnetic resonance imaging (RS-fMRI) was acquired at each status. Regional homogeneity (ReHo) and seed-based whole brain functional connectivity maps (WB-FC maps) were compared.
During sleep, ReHo primarily weakened on frontal lobe (especially preoptic area), but strengthened on brainstem. While during sedation, ReHo changed in various brain areas, including cingulate, precuneus, thalamus and cerebellum. Cingulate, fusiform and insula were concomitance of sleep and sedation. Comparing to sleep, FCs between the cortex and subcortical centers (centralized in cerebellum) were significantly attenuated under sedation. As sedation deepening, cerebellum-based FC maps were diminished, while thalamus- and brainstem-based FC maps were increased.
There're huge distinctions in human brain function between sleep and GA. Sleep mainly rely on brainstem and frontal lobe function, while sedation is prone to affect widespread functional network. The most significant differences exist in the precuneus and cingulate, which may play important roles in mechanisms of inducing unconciousness by anesthetics.
Institutional Review Board (IRB) ChiCTR-IOC-15007454.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0192358</identifier><identifier>PMID: 29486001</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anesthesia ; Anesthesiology ; Anesthetics ; Biology and Life Sciences ; Brain ; Brain mapping ; Brain research ; Brain stem ; Cerebellum ; Comparative analysis ; Connectivity ; Consciousness ; Correlation analysis ; Cortex (cingulate) ; Cortex (frontal) ; Cortex (parietal) ; Data processing ; Drug dosages ; EEG ; Frontal lobe ; Functional magnetic resonance imaging ; General anesthesia ; Homogeneity ; Image acquisition ; In vivo methods and tests ; Information processing ; Intravenous administration ; Magnetic resonance ; Magnetic resonance imaging ; Medical examination ; Medicine and Health Sciences ; Neural circuitry ; Neural networks ; Neuroimaging ; NREM sleep ; Patient outcomes ; Physiological aspects ; Preoptic area ; Propofol ; Sleep ; Sleep (NREM) ; Sleep stages ; Thalamus</subject><ispartof>PloS one, 2018-02, Vol.13 (2), p.e0192358-e0192358</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Li et al 2018 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-95997b89d1b9149b92d85d106737627b763b327299b1681b125c2c21e91643f63</citedby><cites>FETCH-LOGICAL-c692t-95997b89d1b9149b92d85d106737627b763b327299b1681b125c2c21e91643f63</cites><orcidid>0000-0001-5817-3260</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828450/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828450/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29486001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Wang, Shengpei</creatorcontrib><creatorcontrib>Pan, Chuxiong</creatorcontrib><creatorcontrib>Xue, Fushan</creatorcontrib><creatorcontrib>Xian, Junfang</creatorcontrib><creatorcontrib>Huang, Yaqi</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Li, Tianzuo</creatorcontrib><creatorcontrib>He, Huiguang</creatorcontrib><title>Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The mechanism of general anesthesia (GA) has been explored for hundreds of years, but unclear. Previous studies indicated a possible correlation between NREM sleep and GA. The purpose of this study is to compare them by in vivo human brain function to probe the neuromechanism of consciousness, so as to find out a clue to GA mechanism.
24 healthy participants were equally assigned to sleep or propofol sedation group by sleeping ability. EEG and Ramsay Sedation Scale were applied to determine sleep stage and sedation depth respectively. Resting-state functional magnetic resonance imaging (RS-fMRI) was acquired at each status. Regional homogeneity (ReHo) and seed-based whole brain functional connectivity maps (WB-FC maps) were compared.
During sleep, ReHo primarily weakened on frontal lobe (especially preoptic area), but strengthened on brainstem. While during sedation, ReHo changed in various brain areas, including cingulate, precuneus, thalamus and cerebellum. Cingulate, fusiform and insula were concomitance of sleep and sedation. Comparing to sleep, FCs between the cortex and subcortical centers (centralized in cerebellum) were significantly attenuated under sedation. As sedation deepening, cerebellum-based FC maps were diminished, while thalamus- and brainstem-based FC maps were increased.
There're huge distinctions in human brain function between sleep and GA. Sleep mainly rely on brainstem and frontal lobe function, while sedation is prone to affect widespread functional network. The most significant differences exist in the precuneus and cingulate, which may play important roles in mechanisms of inducing unconciousness by anesthetics.
Institutional Review Board (IRB) ChiCTR-IOC-15007454.</description><subject>Anesthesia</subject><subject>Anesthesiology</subject><subject>Anesthetics</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Brain research</subject><subject>Brain stem</subject><subject>Cerebellum</subject><subject>Comparative analysis</subject><subject>Connectivity</subject><subject>Consciousness</subject><subject>Correlation analysis</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Cortex (parietal)</subject><subject>Data processing</subject><subject>Drug dosages</subject><subject>EEG</subject><subject>Frontal lobe</subject><subject>Functional magnetic resonance imaging</subject><subject>General anesthesia</subject><subject>Homogeneity</subject><subject>Image acquisition</subject><subject>In vivo methods and tests</subject><subject>Information processing</subject><subject>Intravenous administration</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Medical examination</subject><subject>Medicine and Health Sciences</subject><subject>Neural circuitry</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>NREM sleep</subject><subject>Patient outcomes</subject><subject>Physiological aspects</subject><subject>Preoptic area</subject><subject>Propofol</subject><subject>Sleep</subject><subject>Sleep (NREM)</subject><subject>Sleep 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of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia</title><author>Li, Yun ; Wang, Shengpei ; Pan, Chuxiong ; Xue, Fushan ; Xian, Junfang ; Huang, Yaqi ; Wang, Xiaoyi ; Li, Tianzuo ; He, Huiguang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-95997b89d1b9149b92d85d106737627b763b327299b1681b125c2c21e91643f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anesthesia</topic><topic>Anesthesiology</topic><topic>Anesthetics</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Brain mapping</topic><topic>Brain research</topic><topic>Brain stem</topic><topic>Cerebellum</topic><topic>Comparative analysis</topic><topic>Connectivity</topic><topic>Consciousness</topic><topic>Correlation analysis</topic><topic>Cortex (cingulate)</topic><topic>Cortex 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yun</au><au>Wang, Shengpei</au><au>Pan, Chuxiong</au><au>Xue, Fushan</au><au>Xian, Junfang</au><au>Huang, Yaqi</au><au>Wang, Xiaoyi</au><au>Li, Tianzuo</au><au>He, Huiguang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-02-27</date><risdate>2018</risdate><volume>13</volume><issue>2</issue><spage>e0192358</spage><epage>e0192358</epage><pages>e0192358-e0192358</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The mechanism of general anesthesia (GA) has been explored for hundreds of years, but unclear. Previous studies indicated a possible correlation between NREM sleep and GA. The purpose of this study is to compare them by in vivo human brain function to probe the neuromechanism of consciousness, so as to find out a clue to GA mechanism.
24 healthy participants were equally assigned to sleep or propofol sedation group by sleeping ability. EEG and Ramsay Sedation Scale were applied to determine sleep stage and sedation depth respectively. Resting-state functional magnetic resonance imaging (RS-fMRI) was acquired at each status. Regional homogeneity (ReHo) and seed-based whole brain functional connectivity maps (WB-FC maps) were compared.
During sleep, ReHo primarily weakened on frontal lobe (especially preoptic area), but strengthened on brainstem. While during sedation, ReHo changed in various brain areas, including cingulate, precuneus, thalamus and cerebellum. Cingulate, fusiform and insula were concomitance of sleep and sedation. Comparing to sleep, FCs between the cortex and subcortical centers (centralized in cerebellum) were significantly attenuated under sedation. As sedation deepening, cerebellum-based FC maps were diminished, while thalamus- and brainstem-based FC maps were increased.
There're huge distinctions in human brain function between sleep and GA. Sleep mainly rely on brainstem and frontal lobe function, while sedation is prone to affect widespread functional network. The most significant differences exist in the precuneus and cingulate, which may play important roles in mechanisms of inducing unconciousness by anesthetics.
Institutional Review Board (IRB) ChiCTR-IOC-15007454.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29486001</pmid><doi>10.1371/journal.pone.0192358</doi><tpages>e0192358</tpages><orcidid>https://orcid.org/0000-0001-5817-3260</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Anesthesia Anesthesiology Anesthetics Biology and Life Sciences Brain Brain mapping Brain research Brain stem Cerebellum Comparative analysis Connectivity Consciousness Correlation analysis Cortex (cingulate) Cortex (frontal) Cortex (parietal) Data processing Drug dosages EEG Frontal lobe Functional magnetic resonance imaging General anesthesia Homogeneity Image acquisition In vivo methods and tests Information processing Intravenous administration Magnetic resonance Magnetic resonance imaging Medical examination Medicine and Health Sciences Neural circuitry Neural networks Neuroimaging NREM sleep Patient outcomes Physiological aspects Preoptic area Propofol Sleep Sleep (NREM) Sleep stages Thalamus |
| title | Comparison of NREM sleep and intravenous sedation through local information processing and whole brain network to explore the mechanism of general anesthesia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T11%3A21%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20NREM%20sleep%20and%20intravenous%20sedation%20through%20local%20information%20processing%20and%20whole%20brain%20network%20to%20explore%20the%20mechanism%20of%20general%20anesthesia&rft.jtitle=PloS%20one&rft.au=Li,%20Yun&rft.date=2018-02-27&rft.volume=13&rft.issue=2&rft.spage=e0192358&rft.epage=e0192358&rft.pages=e0192358-e0192358&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0192358&rft_dat=%3Cgale_plos_%3EA529136716%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2008867736&rft_id=info:pmid/29486001&rft_galeid=A529136716&rft_doaj_id=oai_doaj_org_article_d16432566a0b42848a9a5faccb2120fa&rfr_iscdi=true |