PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries

The design of highly diverse phage display libraries is based on assumption that DNA bases are incorporated at similar rates within the randomized sequence. As library complexity increases and expected copy numbers of unique sequences decrease, the exploration of library space becomes sparser and th...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0193332
Hauptverfasser:	Shave, Steven, Mann, Stefan, Koszela, Joanna, Kerr, Alastair, Auer, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Automation Bacteriophages Binding sites Bioinformatics Biological products Biology and Life Sciences Computational Biology Deoxyribonucleic acid Displays DNA Escherichia coli Gene sequencing Genomic libraries Immunoglobulins Immunology Libraries Medical schools Medical screening Molecular biology Nucleotide sequence Oligonucleotides - genetics Oligonucleotides - metabolism Peptide Library Peptides Phage display Phages Physiological aspects Proteins Quality control Research and Analysis Methods Software
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