The characteristics of residents with unawareness of hepatitis C virus infection in community
Control of hepatitis C virus infection (HCV) is an increasingly important issue. Enhancing screening coverage is necessary to discover more HCV infected subjects in community. However, a substantial population is unaware of HCV infection that needs more attention. The aims of this study were to eval...
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| description | Control of hepatitis C virus infection (HCV) is an increasingly important issue. Enhancing screening coverage is necessary to discover more HCV infected subjects in community. However, a substantial population is unaware of HCV infection that needs more attention.
The aims of this study were to evaluate the status of HCV infected residents in remote villages, to compare characteristics between already known and unaware HCV infection subjects, and to analyze the disease insights.
Screening intervention for liver diseases was conducted in remote villages of Tainan City of southern Taiwan from August 2014 to July 2016. Items of screening examinations included questionnaire, blood sampling for liver tests and viral hepatitis markers (hepatitis B surface antigen and anti-HCV antibody), abdominal sonography survey, and liver stiffness measurement by transient elastography. Quantitation of HCV RNA was measured for residents with positive anti-HCV antibody.
A total of 194 (13.5%) out of 1439 participants showed positive for anti-HCV antibody. HCV viremia was detected in 119 (61.3%) residents. Previously unaware HCV infection by questionnaire record was present in 68 (35.1%) of ant-HCV positive residents. By multivariate logistic analysis, unaware HCV infected residents exhibited significantly mild liver fibrosis (OR 0.876, 95% CI 0.782~0.981, p = 0.022), more prevalent of heart diseases (OR 6.082, 95% CI 1.963~18.839, p = 0.002), and less cluster of family history of liver diseases (OR 0.291, 95% CI 0.113~0.750, p = 0.011) when comparing with already known HCV infected residents. Among the 126 already know HCV infected residents, only 59 (46.8%) received antiviral treatment or regular follow-up. No concept or no willing to receive medical care was observed in 44 (34.9%) residents.
In HCV endemic villages of Taiwan, residents with unaware HCV infection comprised about one third of HCV infected residents and exhibited obscure characteristics to identify. Less than half of already known HCV infected residents received adequate medical care. To eliminate HCV infection, vigorous efforts on enhancing screening coverage, educating update knowledge of liver diseases, and linking to medical care are urgently needed. |
| doi_str_mv | 10.1371/journal.pone.0193251 |
| format | Article |
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The aims of this study were to evaluate the status of HCV infected residents in remote villages, to compare characteristics between already known and unaware HCV infection subjects, and to analyze the disease insights.
Screening intervention for liver diseases was conducted in remote villages of Tainan City of southern Taiwan from August 2014 to July 2016. Items of screening examinations included questionnaire, blood sampling for liver tests and viral hepatitis markers (hepatitis B surface antigen and anti-HCV antibody), abdominal sonography survey, and liver stiffness measurement by transient elastography. Quantitation of HCV RNA was measured for residents with positive anti-HCV antibody.
A total of 194 (13.5%) out of 1439 participants showed positive for anti-HCV antibody. HCV viremia was detected in 119 (61.3%) residents. Previously unaware HCV infection by questionnaire record was present in 68 (35.1%) of ant-HCV positive residents. By multivariate logistic analysis, unaware HCV infected residents exhibited significantly mild liver fibrosis (OR 0.876, 95% CI 0.782~0.981, p = 0.022), more prevalent of heart diseases (OR 6.082, 95% CI 1.963~18.839, p = 0.002), and less cluster of family history of liver diseases (OR 0.291, 95% CI 0.113~0.750, p = 0.011) when comparing with already known HCV infected residents. Among the 126 already know HCV infected residents, only 59 (46.8%) received antiviral treatment or regular follow-up. No concept or no willing to receive medical care was observed in 44 (34.9%) residents.
In HCV endemic villages of Taiwan, residents with unaware HCV infection comprised about one third of HCV infected residents and exhibited obscure characteristics to identify. Less than half of already known HCV infected residents received adequate medical care. To eliminate HCV infection, vigorous efforts on enhancing screening coverage, educating update knowledge of liver diseases, and linking to medical care are urgently needed.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0193251</identifier><identifier>PMID: 29470547</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antibodies ; Antiviral agents ; Baby boomers ; Biology and life sciences ; Blood tests ; Cardiovascular diseases ; Communities ; Coronary artery disease ; Diabetes ; Disease prevention ; Fibrosis ; Gastroenterology ; Genetics ; Health aspects ; Health care ; Heart diseases ; Hepatitis ; Hepatitis B ; Hepatitis B surface antigen ; Hepatitis C ; Hepatitis C virus ; Hepatology ; Hospitals ; Infection ; Infections ; Internal medicine ; Liver ; Liver diseases ; Medicine ; Medicine and health sciences ; People and Places ; Quantitation ; Ribonucleic acid ; RNA ; Screening ; Stiffness ; Studies ; Surveys ; Ultrasonic imaging ; Villages ; Viremia ; Viruses</subject><ispartof>PloS one, 2018-02, Vol.13 (2), p.e0193251-e0193251</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Cheng et al 2018 Cheng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-610914c0a929ea8fc555141870cd37af23594adc178c327952a566e986bc7dd13</citedby><cites>FETCH-LOGICAL-c692t-610914c0a929ea8fc555141870cd37af23594adc178c327952a566e986bc7dd13</cites><orcidid>0000-0001-9331-9018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823433/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823433/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29470547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khudyakov, Yury E</contributor><creatorcontrib>Cheng, Pin-Nan</creatorcontrib><creatorcontrib>Chiu, Yen-Cheng</creatorcontrib><creatorcontrib>Chiu, Hung-Chih</creatorcontrib><creatorcontrib>Chien, Shih-Chieh</creatorcontrib><title>The characteristics of residents with unawareness of hepatitis C virus infection in community</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Control of hepatitis C virus infection (HCV) is an increasingly important issue. Enhancing screening coverage is necessary to discover more HCV infected subjects in community. However, a substantial population is unaware of HCV infection that needs more attention.
The aims of this study were to evaluate the status of HCV infected residents in remote villages, to compare characteristics between already known and unaware HCV infection subjects, and to analyze the disease insights.
Screening intervention for liver diseases was conducted in remote villages of Tainan City of southern Taiwan from August 2014 to July 2016. Items of screening examinations included questionnaire, blood sampling for liver tests and viral hepatitis markers (hepatitis B surface antigen and anti-HCV antibody), abdominal sonography survey, and liver stiffness measurement by transient elastography. Quantitation of HCV RNA was measured for residents with positive anti-HCV antibody.
A total of 194 (13.5%) out of 1439 participants showed positive for anti-HCV antibody. HCV viremia was detected in 119 (61.3%) residents. Previously unaware HCV infection by questionnaire record was present in 68 (35.1%) of ant-HCV positive residents. By multivariate logistic analysis, unaware HCV infected residents exhibited significantly mild liver fibrosis (OR 0.876, 95% CI 0.782~0.981, p = 0.022), more prevalent of heart diseases (OR 6.082, 95% CI 1.963~18.839, p = 0.002), and less cluster of family history of liver diseases (OR 0.291, 95% CI 0.113~0.750, p = 0.011) when comparing with already known HCV infected residents. Among the 126 already know HCV infected residents, only 59 (46.8%) received antiviral treatment or regular follow-up. No concept or no willing to receive medical care was observed in 44 (34.9%) residents.
In HCV endemic villages of Taiwan, residents with unaware HCV infection comprised about one third of HCV infected residents and exhibited obscure characteristics to identify. Less than half of already known HCV infected residents received adequate medical care. To eliminate HCV infection, vigorous efforts on enhancing screening coverage, educating update knowledge of liver diseases, and linking to medical care are urgently needed.</description><subject>Analysis</subject><subject>Antibodies</subject><subject>Antiviral agents</subject><subject>Baby boomers</subject><subject>Biology and life sciences</subject><subject>Blood tests</subject><subject>Cardiovascular diseases</subject><subject>Communities</subject><subject>Coronary artery disease</subject><subject>Diabetes</subject><subject>Disease prevention</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Heart diseases</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B surface antigen</subject><subject>Hepatitis C</subject><subject>Hepatitis C virus</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Infection</subject><subject>Infections</subject><subject>Internal medicine</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine and health sciences</subject><subject>People and Places</subject><subject>Quantitation</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Screening</subject><subject>Stiffness</subject><subject>Studies</subject><subject>Surveys</subject><subject>Ultrasonic imaging</subject><subject>Villages</subject><subject>Viremia</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9EBQfRi13xOkhuhLFUXCgWt3knIZpKdLDOTNcm09t83252WHemFzMUckue8yXlzTlG8hmAOMYOfNn4IvWrnW9-bOYACIwqfFMe7YFYhgJ8exEfFixg3AFDMq-p5cYQEYYASdlz8vmxMqRsVlE4muJicjqW3ZTDR1aZPsbx2qSmHXl2rYHoT73Ybs1XJJRfLRXnlwhBL11ujk_N9jkrtu27oXbp5WTyzqo3m1fg_KX5-ObtcfJudX3xdLk7PZ7oSKM0qCAQkGiiBhFHcakopJJAzoGvMlEWYCqJqDRnXGDFBkaJVZQSvVprVNcQnxdu97rb1UY7ORIkAYIRxhlEmlnui9mojt8F1KtxIr5y8W_BhLVXIxbdGEmaycZZWxFqyWiluapu9QsxSDqhaZa3P42nDqjO1zjYF1U5Epzu9a-TaX0nKESYYZ4EPo0DwfwYTk-xc1KZtVW_8sL-3YFxUIqPv_kEfr26k1ioXkN_C53P1TlSeUsSznZTwTM0fofJXm87p3EbW5fVJwsdJQmaS-ZvWaohRLn98_3_24teUfX_ANka1qYm-HXb9E6cg2YM6-BiDsQ8mQyB3U3DvhtxNgRynIKe9OXygh6T7tse3YGICSw</recordid><startdate>20180222</startdate><enddate>20180222</enddate><creator>Cheng, 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characteristics of residents with unawareness of hepatitis C virus infection in community</title><author>Cheng, Pin-Nan ; Chiu, Yen-Cheng ; Chiu, Hung-Chih ; Chien, Shih-Chieh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-610914c0a929ea8fc555141870cd37af23594adc178c327952a566e986bc7dd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Antibodies</topic><topic>Antiviral agents</topic><topic>Baby boomers</topic><topic>Biology and life sciences</topic><topic>Blood tests</topic><topic>Cardiovascular diseases</topic><topic>Communities</topic><topic>Coronary artery disease</topic><topic>Diabetes</topic><topic>Disease prevention</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Heart diseases</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B surface antigen</topic><topic>Hepatitis C</topic><topic>Hepatitis C virus</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Infection</topic><topic>Infections</topic><topic>Internal medicine</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medicine</topic><topic>Medicine and health sciences</topic><topic>People and Places</topic><topic>Quantitation</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Screening</topic><topic>Stiffness</topic><topic>Studies</topic><topic>Surveys</topic><topic>Ultrasonic imaging</topic><topic>Villages</topic><topic>Viremia</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Pin-Nan</creatorcontrib><creatorcontrib>Chiu, Yen-Cheng</creatorcontrib><creatorcontrib>Chiu, Hung-Chih</creatorcontrib><creatorcontrib>Chien, 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One</addtitle><date>2018-02-22</date><risdate>2018</risdate><volume>13</volume><issue>2</issue><spage>e0193251</spage><epage>e0193251</epage><pages>e0193251-e0193251</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Control of hepatitis C virus infection (HCV) is an increasingly important issue. Enhancing screening coverage is necessary to discover more HCV infected subjects in community. However, a substantial population is unaware of HCV infection that needs more attention.
The aims of this study were to evaluate the status of HCV infected residents in remote villages, to compare characteristics between already known and unaware HCV infection subjects, and to analyze the disease insights.
Screening intervention for liver diseases was conducted in remote villages of Tainan City of southern Taiwan from August 2014 to July 2016. Items of screening examinations included questionnaire, blood sampling for liver tests and viral hepatitis markers (hepatitis B surface antigen and anti-HCV antibody), abdominal sonography survey, and liver stiffness measurement by transient elastography. Quantitation of HCV RNA was measured for residents with positive anti-HCV antibody.
A total of 194 (13.5%) out of 1439 participants showed positive for anti-HCV antibody. HCV viremia was detected in 119 (61.3%) residents. Previously unaware HCV infection by questionnaire record was present in 68 (35.1%) of ant-HCV positive residents. By multivariate logistic analysis, unaware HCV infected residents exhibited significantly mild liver fibrosis (OR 0.876, 95% CI 0.782~0.981, p = 0.022), more prevalent of heart diseases (OR 6.082, 95% CI 1.963~18.839, p = 0.002), and less cluster of family history of liver diseases (OR 0.291, 95% CI 0.113~0.750, p = 0.011) when comparing with already known HCV infected residents. Among the 126 already know HCV infected residents, only 59 (46.8%) received antiviral treatment or regular follow-up. No concept or no willing to receive medical care was observed in 44 (34.9%) residents.
In HCV endemic villages of Taiwan, residents with unaware HCV infection comprised about one third of HCV infected residents and exhibited obscure characteristics to identify. Less than half of already known HCV infected residents received adequate medical care. To eliminate HCV infection, vigorous efforts on enhancing screening coverage, educating update knowledge of liver diseases, and linking to medical care are urgently needed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29470547</pmid><doi>10.1371/journal.pone.0193251</doi><tpages>e0193251</tpages><orcidid>https://orcid.org/0000-0001-9331-9018</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); Public Library of Science; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Analysis Antibodies Antiviral agents Baby boomers Biology and life sciences Blood tests Cardiovascular diseases Communities Coronary artery disease Diabetes Disease prevention Fibrosis Gastroenterology Genetics Health aspects Health care Heart diseases Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis C Hepatitis C virus Hepatology Hospitals Infection Infections Internal medicine Liver Liver diseases Medicine Medicine and health sciences People and Places Quantitation Ribonucleic acid RNA Screening Stiffness Studies Surveys Ultrasonic imaging Villages Viremia Viruses |
| title | The characteristics of residents with unawareness of hepatitis C virus infection in community |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T18%3A57%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20characteristics%20of%20residents%20with%20unawareness%20of%20hepatitis%20C%20virus%20infection%20in%20community&rft.jtitle=PloS%20one&rft.au=Cheng,%20Pin-Nan&rft.date=2018-02-22&rft.volume=13&rft.issue=2&rft.spage=e0193251&rft.epage=e0193251&rft.pages=e0193251-e0193251&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0193251&rft_dat=%3Cgale_plos_%3EA528555548%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2007478732&rft_id=info:pmid/29470547&rft_galeid=A528555548&rft_doaj_id=oai_doaj_org_article_47e193f564ff4bba8edf54727f5805ab&rfr_iscdi=true |