A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics

In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type CaV1.2 channels (LTCCs), which trigger the release of calcium (Ca2+) from the sarcoplasmic reticulum (SR). This results in an increase in intracellular Ca2+ (Cai) that i...

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Veröffentlicht in:	PLoS computational biology 2018-01, Vol.14 (1), p.e1005906-e1005906
Hauptverfasser:	Sato, Daisuke, Dixon, Rose E, Santana, Luis F, Navedo, Manuel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials Animals Arrhythmias, Cardiac - physiopathology Biology and Life Sciences Calcium Calcium (intracellular) Calcium (reticular) Calcium - chemistry Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Calcium Channels, L-Type - metabolism Calcium ions Calcium Signaling Calcium signalling Cardiac muscle Channel gating Channels Computational Biology Computer applications Computer Simulation Coupling Depolarization Electric potential Excitation Contraction Coupling Funding Heart Heart diseases Heart Rate Intracellular Markov Chains Mathematical analysis Mathematical models Medicine and Health Sciences Membrane potential Models, Biological Myocardial Contraction Myocardium - cytology Myocytes Myocytes, Cardiac - cytology Normal Distribution Pharmacology Physical Sciences Physiology Programming Languages Rabbits Rodents Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Stability Stochastic Processes Studies Substrates Supervision Ventricle
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