Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice

The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza infection is often associated with dysr...

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Veröffentlicht in:	PLoS pathogens 2018-01, Vol.14 (1), p.e1006821-e1006821
Hauptverfasser:	Li, Hui, Bradley, Konrad C, Long, Jason S, Frise, Rebecca, Ashcroft, Jonathan W, Hartgroves, Lorian C, Shelton, Holly, Makris, Spyridon, Johansson, Cecilia, Cao, Bin, Barclay, Wendy S
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Analysis Animals Avian flu Avian influenza viruses Biology and life sciences Bone marrow Cells, Cultured Cytokines Dendritic cells Dogs Epithelial cells Female Funding Genes Genes, Viral - physiology Health aspects HEK293 Cells Humans Immune response Immune system Immunity, Innate - physiology Infection Infections Inflammation Influenza Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - pathogenicity Influenza A Virus, H5N1 Subtype - physiology Influenza, Human - genetics Influenza, Human - immunology Influenza, Human - virology Innate immunity Interferon Ligands Lungs Madin Darby Canine Kidney Cells Medicine Medicine and health sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Myeloid cells Myeloid Cells - immunology Myeloid Cells - metabolism Myeloid Cells - virology NS1 protein Orthomyxoviridae Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - virology Pandemics Phenotypes Public health Replication Segments Severity of Illness Index Virology Virus replication Virus Replication - genetics Viruses Zoonoses
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