The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection

Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasi...

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Veröffentlicht in:	PLoS neglected tropical diseases 2018-01, Vol.12 (1), p.e0006170
Hauptverfasser:	Crispim, Marcell, Damasceno, Flávia Silva, Hernández, Agustín, Barisón, María Julia, Pretto Sauter, Ismael, Souza Pavani, Raphael, Santos Moura, Alexandre, Pral, Elizabeth Mieko Furusho, Cortez, Mauro, Elias, Maria Carolina, Silber, Ariel Mariano
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Amino acids Ammonium Ammonium compounds ATP Biochemistry Biology and Life Sciences Carbon sources Care and treatment Cations Cell cycle Chagas disease Consumption Diagnosis Divalent cations Enzymes Etiology Gene expression Glutamate-ammonia ligase Glutamine Immunofluorescence Immunology Infections Intracellular Laboratories Leishmania Life cycle Life cycle engineering Life cycles Localization Mammals Medicine and Health Sciences Metabolism Metabolites Methionine Methods Mineral nutrients Mitochondria Niches Nitrogen balance Nutrient availability Nutrient cycles Parasites Parasitology Parasitophorous vacuole Physical Sciences Protozoa Saccharomyces cerevisiae Secretion Supervision Toxic wastes Toxicity Tropical diseases Trypanosoma cruzi Urea Vector-borne diseases Yeast Yields
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