Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis
By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits. This review was prospectively registered in the PROSPERO database (CRD4201...
Gespeichert in:
| Veröffentlicht in: | PLoS neglected tropical diseases 2018-01, Vol.12 (1), p.e0005524-e0005524 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0005524 |
|---|---|
| container_issue | 1 |
| container_start_page | e0005524 |
| container_title | PLoS neglected tropical diseases |
| container_volume | 12 |
| creator | Ezeamama, Amara E Bustinduy, Amaya L Nkwata, Allan K Martinez, Leonardo Pabalan, Noel Boivin, Michael J King, Charles H |
| description | By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.
This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design.
Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits.
ClinicalTrials.gov CRD42016040052. |
| doi_str_mv | 10.1371/journal.pntd.0005524 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2002618211</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A525917218</galeid><doaj_id>oai_doaj_org_article_b9338914334d46aeb26bae9f1701a131</doaj_id><sourcerecordid>A525917218</sourcerecordid><originalsourceid>FETCH-LOGICAL-c624t-8c6bda5fe13aec8296fea34603a544ceb037e544679f6a445a66b185cffb47ea3</originalsourceid><addsrcrecordid>eNptktuK2zAQhk1p6W7TvkFpDYXSG6fW0dbNQgg9LCz0pr0WsjxOFGwrteQsefuON94lKYtB1uGbfzSjP0nek3xJWEG-7vw49KZd7vtYL_M8F4LyF8k1UUxktGDi5dn8KnkTwg4ZJUryOrmiilGFw3US137Tu-gOkNbQOOtiSE1fp1CP1kTnMUPa-hBS16d269p6gD69d3GbBlyG6IPvAA8bsBOdrdJwDBE6jLXpAAcH9w96HUSTGVQ7BhfeJq8a0wZ4N_8XyZ_v336vf2Z3v37crld3mZWUx6y0sqqNaIAwA7akSjZgGJc5M4JzC1XOCsCZLFQjDefCSFmRUtimqXiB6CL5eNLdYwl6bljQNM-pJCUlBInbE1F7s9P7wXVmOGpvnH7Y8MNGmwFLaUFXirFSEc4Yr7k0UFFZGVANKXJiCJu0buZsY9VBbaGPg2kvRC9PerfVG3_QopCS4Gsski-zwOD_jhCi7lyw0LamBz8GTVSpRCEYEYh--g99vrqZ2hgsAB_JY147ieqVoEKRgpISqeUzFH41dM76Hm2B-xcBn88CtmDauA2-HScDhEuQn0A7oIUGaJ6aQXI9mfjx1noysZ5NjGEfzhv5FPToWvYPb8jv1Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2002618211</pqid></control><display><type>article</type><title>Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Ezeamama, Amara E ; Bustinduy, Amaya L ; Nkwata, Allan K ; Martinez, Leonardo ; Pabalan, Noel ; Boivin, Michael J ; King, Charles H</creator><creatorcontrib>Ezeamama, Amara E ; Bustinduy, Amaya L ; Nkwata, Allan K ; Martinez, Leonardo ; Pabalan, Noel ; Boivin, Michael J ; King, Charles H</creatorcontrib><description>By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.
This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design.
Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits.
ClinicalTrials.gov CRD42016040052.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0005524</identifier><identifier>PMID: 29329293</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Animals ; Anthelmintics - therapeutic use ; Biology and Life Sciences ; Child ; Child, Preschool ; Children ; Cognition ; Cognition & reasoning ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - parasitology ; Confidence intervals ; Design ; Education ; Educational aspects ; Elementary school students ; Epidemiology ; Health aspects ; Humans ; Hygiene ; Infections ; Intelligence ; Intelligence - physiology ; Learning ; Learning Disorders - parasitology ; Medicine ; Medicine and Health Sciences ; Memory ; Memory - physiology ; Memory and Learning Tests ; Memory Disorders - parasitology ; Meta-analysis ; Osteopathic medicine ; People and Places ; Praziquantel ; Praziquantel - therapeutic use ; Quality assessment ; Quality control ; R&D ; Reaction time ; Reaction Time - physiology ; Research & development ; Risk factors ; Schistosoma ; Schistosoma - pathogenicity ; Schistosoma japonicum ; Schistosoma mansoni ; Schistosomiasis ; Schistosomiasis - complications ; Schistosomiasis - drug therapy ; Schistosomiasis - psychology ; School attendance ; Sensitivity analysis ; Social Sciences ; Studies ; Systematic review ; Tests ; Tropical diseases</subject><ispartof>PLoS neglected tropical diseases, 2018-01, Vol.12 (1), p.e0005524-e0005524</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Ezeamama AE, Bustinduy AL, Nkwata AK, Martinez L, Pabalan N, Boivin MJ, et al. (2018) Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. PLoS Negl Trop Dis 12(1): e0005524. https://doi.org/10.1371/journal.pntd.0005524</rights><rights>2018 Ezeamama et al 2018 Ezeamama et al</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Ezeamama AE, Bustinduy AL, Nkwata AK, Martinez L, Pabalan N, Boivin MJ, et al. (2018) Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. PLoS Negl Trop Dis 12(1): e0005524. https://doi.org/10.1371/journal.pntd.0005524</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-8c6bda5fe13aec8296fea34603a544ceb037e544679f6a445a66b185cffb47ea3</citedby><cites>FETCH-LOGICAL-c624t-8c6bda5fe13aec8296fea34603a544ceb037e544679f6a445a66b185cffb47ea3</cites><orcidid>0000-0003-2164-8802</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766129/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766129/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29329293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ezeamama, Amara E</creatorcontrib><creatorcontrib>Bustinduy, Amaya L</creatorcontrib><creatorcontrib>Nkwata, Allan K</creatorcontrib><creatorcontrib>Martinez, Leonardo</creatorcontrib><creatorcontrib>Pabalan, Noel</creatorcontrib><creatorcontrib>Boivin, Michael J</creatorcontrib><creatorcontrib>King, Charles H</creatorcontrib><title>Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.
This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design.
Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits.
ClinicalTrials.gov CRD42016040052.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Anthelmintics - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - parasitology</subject><subject>Confidence intervals</subject><subject>Design</subject><subject>Education</subject><subject>Educational aspects</subject><subject>Elementary school students</subject><subject>Epidemiology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Infections</subject><subject>Intelligence</subject><subject>Intelligence - physiology</subject><subject>Learning</subject><subject>Learning Disorders - parasitology</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Memory - physiology</subject><subject>Memory and Learning Tests</subject><subject>Memory Disorders - parasitology</subject><subject>Meta-analysis</subject><subject>Osteopathic medicine</subject><subject>People and Places</subject><subject>Praziquantel</subject><subject>Praziquantel - therapeutic use</subject><subject>Quality assessment</subject><subject>Quality control</subject><subject>R&D</subject><subject>Reaction time</subject><subject>Reaction Time - physiology</subject><subject>Research & development</subject><subject>Risk factors</subject><subject>Schistosoma</subject><subject>Schistosoma - pathogenicity</subject><subject>Schistosoma japonicum</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis - complications</subject><subject>Schistosomiasis - drug therapy</subject><subject>Schistosomiasis - psychology</subject><subject>School attendance</subject><subject>Sensitivity analysis</subject><subject>Social Sciences</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Tests</subject><subject>Tropical diseases</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptktuK2zAQhk1p6W7TvkFpDYXSG6fW0dbNQgg9LCz0pr0WsjxOFGwrteQsefuON94lKYtB1uGbfzSjP0nek3xJWEG-7vw49KZd7vtYL_M8F4LyF8k1UUxktGDi5dn8KnkTwg4ZJUryOrmiilGFw3US137Tu-gOkNbQOOtiSE1fp1CP1kTnMUPa-hBS16d269p6gD69d3GbBlyG6IPvAA8bsBOdrdJwDBE6jLXpAAcH9w96HUSTGVQ7BhfeJq8a0wZ4N_8XyZ_v336vf2Z3v37crld3mZWUx6y0sqqNaIAwA7akSjZgGJc5M4JzC1XOCsCZLFQjDefCSFmRUtimqXiB6CL5eNLdYwl6bljQNM-pJCUlBInbE1F7s9P7wXVmOGpvnH7Y8MNGmwFLaUFXirFSEc4Yr7k0UFFZGVANKXJiCJu0buZsY9VBbaGPg2kvRC9PerfVG3_QopCS4Gsski-zwOD_jhCi7lyw0LamBz8GTVSpRCEYEYh--g99vrqZ2hgsAB_JY147ieqVoEKRgpISqeUzFH41dM76Hm2B-xcBn88CtmDauA2-HScDhEuQn0A7oIUGaJ6aQXI9mfjx1noysZ5NjGEfzhv5FPToWvYPb8jv1Q</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Ezeamama, Amara E</creator><creator>Bustinduy, Amaya L</creator><creator>Nkwata, Allan K</creator><creator>Martinez, Leonardo</creator><creator>Pabalan, Noel</creator><creator>Boivin, Michael J</creator><creator>King, Charles H</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2164-8802</orcidid></search><sort><creationdate>20180101</creationdate><title>Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis</title><author>Ezeamama, Amara E ; Bustinduy, Amaya L ; Nkwata, Allan K ; Martinez, Leonardo ; Pabalan, Noel ; Boivin, Michael J ; King, Charles H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-8c6bda5fe13aec8296fea34603a544ceb037e544679f6a445a66b185cffb47ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Anthelmintics - therapeutic use</topic><topic>Biology and Life Sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - parasitology</topic><topic>Confidence intervals</topic><topic>Design</topic><topic>Education</topic><topic>Educational aspects</topic><topic>Elementary school students</topic><topic>Epidemiology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Infections</topic><topic>Intelligence</topic><topic>Intelligence - physiology</topic><topic>Learning</topic><topic>Learning Disorders - parasitology</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Memory</topic><topic>Memory - physiology</topic><topic>Memory and Learning Tests</topic><topic>Memory Disorders - parasitology</topic><topic>Meta-analysis</topic><topic>Osteopathic medicine</topic><topic>People and Places</topic><topic>Praziquantel</topic><topic>Praziquantel - therapeutic use</topic><topic>Quality assessment</topic><topic>Quality control</topic><topic>R&D</topic><topic>Reaction time</topic><topic>Reaction Time - physiology</topic><topic>Research & development</topic><topic>Risk factors</topic><topic>Schistosoma</topic><topic>Schistosoma - pathogenicity</topic><topic>Schistosoma japonicum</topic><topic>Schistosoma mansoni</topic><topic>Schistosomiasis</topic><topic>Schistosomiasis - complications</topic><topic>Schistosomiasis - drug therapy</topic><topic>Schistosomiasis - psychology</topic><topic>School attendance</topic><topic>Sensitivity analysis</topic><topic>Social Sciences</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Tests</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ezeamama, Amara E</creatorcontrib><creatorcontrib>Bustinduy, Amaya L</creatorcontrib><creatorcontrib>Nkwata, Allan K</creatorcontrib><creatorcontrib>Martinez, Leonardo</creatorcontrib><creatorcontrib>Pabalan, Noel</creatorcontrib><creatorcontrib>Boivin, Michael J</creatorcontrib><creatorcontrib>King, Charles H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ezeamama, Amara E</au><au>Bustinduy, Amaya L</au><au>Nkwata, Allan K</au><au>Martinez, Leonardo</au><au>Pabalan, Noel</au><au>Boivin, Michael J</au><au>King, Charles H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>12</volume><issue>1</issue><spage>e0005524</spage><epage>e0005524</epage><pages>e0005524-e0005524</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.
This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design.
Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits.
ClinicalTrials.gov CRD42016040052.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29329293</pmid><doi>10.1371/journal.pntd.0005524</doi><orcidid>https://orcid.org/0000-0003-2164-8802</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2018-01, Vol.12 (1), p.e0005524-e0005524 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2002618211 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adolescent Animals Anthelmintics - therapeutic use Biology and Life Sciences Child Child, Preschool Children Cognition Cognition & reasoning Cognition - physiology Cognitive ability Cognitive Dysfunction - parasitology Confidence intervals Design Education Educational aspects Elementary school students Epidemiology Health aspects Humans Hygiene Infections Intelligence Intelligence - physiology Learning Learning Disorders - parasitology Medicine Medicine and Health Sciences Memory Memory - physiology Memory and Learning Tests Memory Disorders - parasitology Meta-analysis Osteopathic medicine People and Places Praziquantel Praziquantel - therapeutic use Quality assessment Quality control R&D Reaction time Reaction Time - physiology Research & development Risk factors Schistosoma Schistosoma - pathogenicity Schistosoma japonicum Schistosoma mansoni Schistosomiasis Schistosomiasis - complications Schistosomiasis - drug therapy Schistosomiasis - psychology School attendance Sensitivity analysis Social Sciences Studies Systematic review Tests Tropical diseases |
| title | Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T06%3A02%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20deficits%20and%20educational%20loss%20in%20children%20with%20schistosome%20infection-A%20systematic%20review%20and%20meta-analysis&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Ezeamama,%20Amara%20E&rft.date=2018-01-01&rft.volume=12&rft.issue=1&rft.spage=e0005524&rft.epage=e0005524&rft.pages=e0005524-e0005524&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0005524&rft_dat=%3Cgale_plos_%3EA525917218%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2002618211&rft_id=info:pmid/29329293&rft_galeid=A525917218&rft_doaj_id=oai_doaj_org_article_b9338914334d46aeb26bae9f1701a131&rfr_iscdi=true |