Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease

Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-related illness, causing significant mortality a...

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Veröffentlicht in:	PLoS neglected tropical diseases 2018-01, Vol.12 (1), p.e0006180-e0006180
Hauptverfasser:	Gaspar, Luís, Coron, Ross P, KongThoo Lin, Paul, Costa, David M, Perez-Cabezas, Begoña, Tavares, Joana, Roura-Ferrer, Meritxell, Ramos, Isbaal, Ronin, Céline, Major, Louise L, Ciesielski, Fabrice, Pemberton, Iain K, MacDougall, Jane, Ciapetti, Paola, Smith, Terry K, Cordeiro-da-Silva, Anabela
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Animals Antiprotozoal Agents - metabolism Benznidazole Biology and Life Sciences Cardiomyopathy Causes of Cell cycle Chagas disease Chagas Disease - drug therapy Chagas Disease - parasitology Chemical kinetics Disease control Disease Models, Animal Diseases Drug discovery Drug therapy Drugs Enzyme Inhibitors - metabolism Epimastigotes Formulations Funding Genetic aspects Health aspects Heart Inhibitors Medicine and Health Sciences Mice Morbidity NAD Niacinamide - metabolism Nicotinamide Parasites Parasitic diseases Pharmaceutical sciences Pharmacokinetics Pharmacology Physical Sciences Physiological aspects Proteins Protozoa Protozoan Proteins - antagonists & inhibitors Quinolones - metabolism R&D Research & development Sirtuins Specificity Spermidine Spermine - analogs & derivatives Spermine - metabolism Substrates Supervision Treatment Outcome Tropical diseases Trypanosoma cruzi Trypanosoma cruzi - drug effects Vector-borne diseases
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