Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates expression of low-density lipoprotein (LDL) receptors via receptor internalization and subsequent lysosomal degradation. Thus, an anti-PCSK9 antibody is well known as an anti-hyperlipidemia drug. Here, we aimed to develop vaccine for a...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0191895-e0191895
Hauptverfasser:	Kawakami, Ryo, Nozato, Yoichi, Nakagami, Hironori, Ikeda, Yuka, Shimamura, Munehisa, Yoshida, Shota, Sun, Jiao, Kawano, Tomohiro, Takami, Yoichi, Noma, Takahisa, Rakugi, Hiromi, Minamino, Tetsuo, Morishita, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Amino acids Antibody response Antigens Apolipoprotein E Apolipoproteins Atherosclerosis Binding sites Biology and Life Sciences Cardiovascular disease Care and treatment Cell activation Cell receptors Cell surface Cholesterol Development and progression Drug dosages Dyslipidemia Dyslipidemias Enzyme-linked immunosorbent assay Epitopes Gene therapy Geriatrics Health aspects Hyperlipidemia Immunization Immunoglobulins Innovations Interleukin 4 Internalization Kexin Laboratory animals Lipoproteins (very low density) Low density lipoprotein Lymphocytes T Lysosomes Medicine Medicine and Health Sciences Metabolic disorders Mice Mutation Peptides Plasma levels Proprotein convertases Receptors Research and Analysis Methods Rodents Subtilisin University graduates Vaccines
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